Rabbit polyclonal CASP9 antibody (A2636)


Reactivity: Human,Mouse
Applications: WB,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CASP9 antibody (A2636)

Supplier: ABclonal Inc.

Recommended applications: WB,IF

Recommended dilution:

WB 1:500 – 1:2000 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CASP9 antibody.

Alternative names:

Check alternative names for the antibody


MCH6 antibody, APAF3 antibody, APAF-3 antibody, PPP1R56 antibody, ICE-LAP6 antibody
APAF-3 antibody|Apoptotic protease Mch-6 antibody|Caspase 9 Dominant Negative antibody|Caspase 9c antibody|Caspase-9 antibody|Caspase-9 subunit p10 antibody|ICE LAP6 antibody|ICE like apoptotic protease 6 antibody|ICE-LAP6 antibody|ICE-like apoptotic protease 6 antibody|MCH6 antibody|PPP1R56 antibody|protein phosphatase 1, regulatory subunit 56 antibody|RNCASP9 antibody|Anti-Caspase-9 antibody [E23] (ab32539)

SCBT cat No: sc-81650|sc-56073|sc-70505|sc-70506|sc-70507|sc-56076|sc-81663|sc-81589|sc-73548|sc-56077|sc-8297|sc-17784|sc-7885|sc-133109|sc-8355|sc-374489|sc-373777|


Rabbit polyclonal CASP9 antibody

Catalogue No.



Human, Mouse


Recombinant protein of human CASP9





Recommended dilution

WB 1:500 – 1:2000
IF 1:50 – 1:100







Molecular weight

Predicted: 46kDa/Observed: Refer to Figures


CASP9 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.


CASP9 antibody was purified using affinity purification.


Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MCH6 antibody, APAF3 antibody, APAF-3 antibody, PPP1R56 antibody, ICE-LAP6 antibody

Database links

Human UniProt/Swiss-Prot:P55211

Protein names


Protein function

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).; Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.

Protein tissue specificity

Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.

Protein sequence and domain

Belongs to the peptidase C14A family.; Contains 1 CARD domain.

Protein post-translational modifications

Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.; Phosphorylated at Thr-125 by MAPK1/ERK2. Phosphorylation at Thr-125 is sufficient to block caspase-9 processing and subsequent caspase-3 activation. Phosphorylation on Tyr-153 by ABL1/c-Abl; occurs in the response of cells to DNA damage.


Caspase-9 (ICE-LAP6, Mch6) is an important member of the cysteine aspartic acid protease (caspase) family (1,2). Upon apoptotic stimulation, cytochrome c released from mitochondria associates with the 47 kDa procaspase-9/Apaf 1. Apaf-1 mediated activation of caspase-9 involves instrinsic proteolytic processing resulting in cleavage at Asp315 and producing a p35 subunit. Another cleavage occurs at Asp330 producing a p37 subunit that can serve to amplify the apoptotic response (3-6). Cleaved caspase-9 further processes other caspase members, including caspase-3 and caspase-7, to initiate a caspase cascade, which leads to apoptosis (7-10).

Research area

All research areas>Tumor Suppressor/Apoptosis>Caspase
(View all antibody categories related to Tumor Suppressor/Apoptosis)


AntibodyPlus can customize CASP9 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody


ABclonal Inc.


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