Rabbit Polyclonal Caspase-1 antibody (STJ98574)

$99.00$319.00

Reactivity: Human, Rat
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Caspase-1 antibody (STJ98574)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CASP1 antibody, IL1BC antibody, IL1BCE antibody,|CASP-1 antibody|CASP1 antibody|CASP1_HUMAN antibody|Caspase 1 antibody|Caspase-1 subunit p10 antibody|ICE antibody|IL-1 beta-converting enzyme antibody|IL-1BC antibody|IL1 beta converting enzyme antibody|IL1B convertase antibody|Interleukin 1 beta convertase antibody|Interleukin 1B converting enzyme antibody|Interleukin-1 beta convertase antibody|Interleukin-1 beta-converting enzyme antibody|p45 antibody|Anti-Caspase-1 antibody
SCBT cat No: sc-514|sc-1780|sc-398715|sc-1597|sc-1218|sc-134299|

Name

Caspase-1 Polyclonal Antibody

Catalogue No.

STJ98574

Reactivity

Human, Rat

Specificity

Caspase-1 Polyclonal Antibody detects endogenous levels of Caspase-1

Immunogen

Synthesized peptide derived from Caspase-1 at AA range internal

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Formulation

Caspase-1 Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Caspase-1 Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Caspase-1 antibody, CASP-1 antibody, Interleukin-1 beta convertase antibody, IL-1BC antibody, Interleukin-1 beta-converting enzyme antibody, ICE antibody, IL-1 beta-converting enzyme antibody, p45 antibody

Database links

Human UniProt/Swiss-Prot:P29466;Mouse UniPort/Swiss-Prot: P29452;Rat UniProt/Swiss-Port: Q91W32;Human Entrez Gene: 834;Mouse Entrez Gene: 12362;Rat Entrez Gene: Rn.37508

Protein names

Caspase-1 , CASP-1 , Interleukin-1 beta convertase , IL-1BC , Interleukin-1 beta-converting enzyme , ICE , IL-1 beta-converting enzyme , p45

Protein function

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. / Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-, -. / Specifically inhibited by the cowpox virus Crma protein.

Protein tissue specificity

Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.

Protein sequence and domain

Belongs to the peptidase C14A family. / Contains 1 CARD domain.

Protein post-translational modifications

The two subunits are derived from the precursor sequence by an autocatalytic mechanism.

Protein cellular localization

Cytoplasm

Research area

All research areas>Tumor Suppressor/Apoptosis>Caspase
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize Caspase-1 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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Immunofluorescence analysis of Rat lung tissue

1: Caspase-1 Polyclonal Antibody(red) was diluted at 1:200 (4 degree Celsius,overnight).
2: Cy3 labled Secondary antibody was diluted at 1:300 (room temperature, 50min).
3: Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B.
 

Immunofluorescence analysis of Rat lung tissue

1: Caspase-1 Polyclonal Antibody(red) was diluted at 1:200 (4 degree Celsius,overnight).
2: Cy3 labled Secondary antibody was diluted at 1:300 (room temperature, 50min).
3: Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B.
 

Immunohistochemical analysis of paraffin embedded Human uterus tissue

1: Caspase-1 Polyclonal Antibody was diluted at 1:200 (4 degree Celsius,overnight).
2: Sodium citrate pH 6.0 was used for antibody retrieval (>98 degree Celsius,20min).
3: Secondary antibody was diluted at 1:200 (room temperature, 30min). Negative control was used by secondary antibody only.
 

Immunohistochemical analysis of paraffin embedded Rat lung tissue

1: Caspase-1 Polyclonal Antibody was diluted at 1:200 (4 degree Celsius,overnight).
2: Sodium citrate pH 6.0 was used for antibody retrieval (>98 degree Celsius,20min).
3: Secondary antibody was diluted at 1:200 (room temperature, 30min). Negative control was used by secondary antibody only.
 

Immunohistochemical analysis of paraffin embedded Rat spleen tissue

1: Caspase-1 Polyclonal Antibody was diluted at 1:200 (4 degree Celsius,overnight).
2: Sodium citrate pH 6.0 was used for antibody retrieval (>98 degree Celsius,20min).
3: Secondary antibody was diluted at 1:200 (room temperature, 30min). Negative control was used by secondary antibody only.
 

Immunohistochemical analysis of paraffin embedded Mouse liver tissue
1: Caspase-1 Polyclonal Antibody was diluted at 1:200 (4 degree Celsius

1: Caspase-1 Polyclonal Antibody was diluted at 1:200 (4 degree Celsius,overnight).
2: Sodium citrate pH 6.0 was used for antibody retrieval (>98 degree Celsius,20min).
3: Secondary antibody was diluted at 1:200 (room temperature, 30min). Negative control was used by secondary antibody only.


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