Rabbit Polyclonal Caspase-14 antibody (STJ90022)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Caspase-14 antibody (STJ90022)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:40000;

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CASP14 antibody,|CASP-5 antibody|CASP5 antibody|CASP5_HUMAN antibody|Caspase-5 subunit p10 antibody|ICE(rel)-III antibody|ICERELIII antibody|ICH 3 antibody|ICH 3 protease antibody|Protease ICH-3 antibody|Protease TY antibody|TY antibody|TY protease antibody|Anti-Caspase-14 antibody [EPR12927] (ab174847)
SCBT cat No: sc-136351|sc-56040|sc-48395|sc-48336|sc-5628|sc-515259|sc-9644|

 

Name

Caspase-14 Polyclonal Antibody

Catalogue No.

STJ90022

Reactivity

Human

Specificity

Caspase-14 Polyclonal Antibody detects endogenous levels of Caspase-14 protein.

Immunogen

Synthesized peptide derived from Caspase-14 at AA range 110-190

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:40000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

27 kDa

Formulation

Caspase-14 Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Caspase-14 Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Caspase-14 antibody, CASP-14 antibody, antibody

Database links

Human UniProt/Swiss-Prot:P31944;Mouse UniPort/Swiss-Prot: O89094;Rat UniProt/Swiss-Port: D3ZZ65;Human Entrez Gene: 23581;Mouse Entrez Gene: 12365;Rat Entrez Gene: Rn.228179

Protein names

Caspase-14 , CASP-14 ,

Protein function

Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum . Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF . Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function . Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD . / Inhibited by caspase-1 inhibitor YVAD-FMK and the pan-caspase inhibitor VAD-FMK.

Protein tissue specificity

Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels (PubMed:11175259). The p17/10 mature form is expressed in epidermis stratum corneum, the p20/p8 intermediate form in epidermis upper granular cells of the stratum granulosum (PubMed:22825846).

Protein sequence and domain

Belongs to the peptidase C14A family.

Protein post-translational modifications

Maturation by proteolytic processing appears to be a two-step process. The precursor is processed by KLK7 to yield the p20/p8 intermediate form which acts on the precursor to yield the p17/p10 mature form . Initially, cleavage between Ile-152 and Lys-153 has been proposed to yield the large and small subunits of the active enzyme .

Protein cellular localization

Cytoplasm / Nucleus

Research area

All research areas>Tumor Suppressor/Apoptosis>Caspase
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize Caspase-14 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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