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Rabbit Polyclonal Caspase-14 antibody (STJ90022)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:40000;
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
CASP14 antibody,|CASP-5 antibody|CASP5 antibody|CASP5_HUMAN antibody|Caspase-5 subunit p10 antibody|ICE(rel)-III antibody|ICERELIII antibody|ICH 3 antibody|ICH 3 protease antibody|Protease ICH-3 antibody|Protease TY antibody|TY antibody|TY protease antibody|Anti-Caspase-14 antibody [EPR12927] (ab174847)
SCBT cat No: sc-136351|sc-56040|sc-48395|sc-48336|sc-5628|sc-515259|sc-9644|
Caspase-14 Polyclonal Antibody
|Catalogue No.|| |
Caspase-14 Polyclonal Antibody detects endogenous levels of Caspase-14 protein.
Synthesized peptide derived from Caspase-14 at AA range 110-190
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:40000;
|Molecular weight|| |
Caspase-14 Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Caspase-14 Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Caspase-14 antibody, CASP-14 antibody, antibody
|Protein names|| |
Caspase-14 , CASP-14 ,
|Protein function|| |
Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum . Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF . Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function . Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD . / Inhibited by caspase-1 inhibitor YVAD-FMK and the pan-caspase inhibitor VAD-FMK.
|Protein tissue specificity|| |
Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels (PubMed:11175259). The p17/10 mature form is expressed in epidermis stratum corneum, the p20/p8 intermediate form in epidermis upper granular cells of the stratum granulosum (PubMed:22825846).
|Protein sequence and domain|| |
Belongs to the peptidase C14A family.
|Protein post-translational modifications|| |
Maturation by proteolytic processing appears to be a two-step process. The precursor is processed by KLK7 to yield the p20/p8 intermediate form which acts on the precursor to yield the p17/p10 mature form . Initially, cleavage between Ile-152 and Lys-153 has been proposed to yield the large and small subunits of the active enzyme .
|Protein cellular localization|| |
Cytoplasm / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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