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Rabbit Polyclonal Caveolin-1 antibody (STJ92050)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for Caveolin-1 Polyclonal Antibody.
Check alternative names for the antibodyExpand
CAV1 antibody, CAV antibody,|BSCL3 antibody|CAV antibody|CAV1 antibody|CAV1_HUMAN antibody|caveolae protein, 22 kD antibody|caveolin 1 alpha isoform antibody|caveolin 1 beta isoform antibody|Caveolin 1 caveolae protein 22kDa antibody|Caveolin-1 antibody|Caveolin1 antibody|cell growth-inhibiting protein 32 antibody|CGL3 antibody|LCCNS antibody|MSTP085 antibody|OTTHUMP00000025031 antibody|PPH3 antibody|VIP 21 antibody|VIP21 antibody|Anti-Caveolin-1 antibody (ab2910)
SCBT cat No: sc-70516|sc-53564|sc-7875|sc-894|sc-30755|sc-30754|sc-7942|sc-1858|
Caveolin-1 Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Caveolin-1 Polyclonal Antibody detects endogenous levels of Caveolin-1 protein.
Synthesized peptide derived from Caveolin-1 at AA range 1-80
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:20000;
|Molecular weight|| |
Caveolin-1 Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Caveolin-1 Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
|Database links|| |
Human UniProt/Swiss-Prot:<a href="http://www.uniprot.org/uniprot/Q03135">Q03135</a>;Mouse UniPort/Swiss-Prot: <a href="http://www.uniprot.org/uniprot/P49817">P49817</a>;Rat UniProt/Swiss-Port: <a href="http://www.uniprot.org/uniprot/Q2IBC6">Q2IBC6</a>;Human Entrez Gene: <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=857">857</a>;Mouse Entrez Gene: <a href="http://www.ncbi.nlm.nih.gov/gene/12389">12389</a>;Rat Entrez Gene: <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Rn&CID=22518">Rn.22518</a>
|Protein names|| |
|Protein function|| |
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation .
|Protein tissue specificity|| |
Expressed in muscle and lung, less so in liver, brain and kidney.
|Involvement in disease|| |
Congenital generalized lipodystrophy 3 (CGL3) [MIM:612526]: An autosomal recessive disorder characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Pulmonary hypertension, primary, 3 (PPH3) [MIM:615343]: A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Partial lipodystrophy, congenital cataracts, and neurodegeneration syndrome (LCCNS) [MIM:606721]: A form of familial partial lipodystrophy associated with congenital cataracts and neurodegeneration leading to cerebellar and spinal cord dysfunction. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the caveolin family.
|Protein post-translational modifications|| |
The initiator methionine for isoform 2 is removed during or just after translation. The new N-terminal amino acid is then N-acetylated. / Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.
|Protein cellular localization|| |
Golgi apparatus membrane; Peripheral membrane protein / Cell membrane; Peripheral membrane protein / Membrane > caveola; Peripheral membrane protein / Membrane raft
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Signaling-Intermediates/">Signaling Intermediates</a>><a href="http://antibodyplus.com/product-tag/Caveolin/">Caveolin</a><br><a href="http://antibodyplus.com/product-tag/Signaling-Intermediates/"> (View all antibody categories related to Signaling Intermediates)</a>
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St John’s Laboratory Ltd.
|Product type|| |
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