Rabbit polyclonal CBFB antibody (A5305)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CBFB antibody (A5305)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CBFB antibody.

Alternative names:

Check alternative names for the antibody

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CBFB antibody,CBF beta antibody,PEBP2B antibody,PEA2 beta antibody,PEBP2 beta antibody
CBF b antibody|CBF beta antibody|CBF-beta antibody|CBFB antibody|CBFbeta antibody|Core binding factor beta subunit antibody|core binding factor subunit beta antibody|Core-binding factor subunit beta antibody|PEA 2 antibody|PEA2 antibody|PEA2 beta antibody|PEA2-beta antibody|PEA2beta antibody|PEBB_HUMAN antibody|PEBP 2B antibody|PEBP2 beta antibody|PEBP2-beta antibody|PEBP2B antibody|PEBP2beta antibody|Polyomavirus enhancer binding protein 2 beta subunit antibody|Polyomavirus enhancer-binding protein 2 beta subunit antibody|SL3 3 enhancer factor 1 beta subunit antibody|SL3 3 enhancer factor 1 subunit beta antibody|SL3-3 enhancer factor 1 subunit beta antibody|SL3/AKV core binding factor beta subunit antibody|SL3/AKV core-binding factor beta subunit antibody|Anti-CBFb antibody [EPR6322] (ab133600)

SCBT cat No: sc-56751|sc-166142|sc-17181|sc-20693|sc-166126|

Name

Rabbit polyclonal CBFB antibody

Catalogue No.

A5305

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CBFB

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 22kDa/Observed: Refer to Figures

Formulation

CBFB antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CBFB antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CBFB antibody,CBF beta antibody,PEBP2B antibody,PEA2 beta antibody,PEBP2 beta antibody

Database links

Human UniProt/Swiss-Prot:Q13951

Protein names

CBFB,CBF beta,PEBP2B,PEA2 beta,PEBP2 beta

Protein function

CBF binds to the core site, 5′-PYGPYGGT-3′, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBFB enhances DNA binding by RUNX1.

Protein sequence and domain

Belongs to the CBF-beta family.

Protein cellular localization

Nucleus .

Background

The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Transcription Regulators>PEBP2
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize CBFB antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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