Rabbit polyclonal CBLC antibody (A7789)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CBLC antibody (A7789)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CBLC antibody.

Alternative names:

Check alternative names for the antibody

Expand

CBL-3 antibody, RNF57 antibody, CBL-SL antibody
Cas Br M (murine) ecotropic retroviral transforming sequence c antibody|Cas Br M (murine) ectropic retroviral transforming sequence c antibody|Casitas B lineage lymphoma c antibody|CBL 3 antibody|Cbl proto-oncogene C, E3 ubiquitin protein ligase antibody|Cbl proto-oncogene, E3 ubiquitin protein ligase C antibody|CBL SL antibody|E3 ubiquitin-protein ligase CBL-C antibody|RING finger protein 57 antibody|RNF57 antibody|SH3 binding protein CBL C antibody|SH3-binding protein CBL-3 antibody|Signal transduction protein CBL C antibody|Anti-Cbl-c antibody (ab34750)

SCBT cat No: sc-8372|sc-390648|sc-390649|

Name

Rabbit polyclonal CBLC antibody

Catalogue No.

A7789

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human CBLC

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 52kDa/Observed: Refer to figures

Formulation

CBLC antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CBLC antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CBL-3 antibody, RNF57 antibody, CBL-SL antibody

Database links

Human UniProt/Swiss-Prot:Q9ULV8

Protein names

CBL-3, RNF57, CBL-SL

Protein function

Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at ‘Tyr-419’. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

EF-hand-like and Sh2-like domains are required for N-terminal inhibition of E3 activity.; The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.; The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain.; Contains 1 RING-type zinc finger.

Protein post-translational modifications

Phosphorylated on multiple tyrosine residues by SRC. Isoform 1, but not isoform 2, is phosphorylated on tyrosines by EGFR.; Autoubiquitinated when phosphorylated at Tyr-341, enhanced by SRC; suggesting proteasomal degradation.

Background

This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Research area

All research areas>Signaling Intermediates>Cbl
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize CBLC antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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