Rabbit polyclonal CBS antibody (A1427)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CBS antibody (A1427)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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HIP4 antibody,CBS antibody
AI047524 antibody|AI303044 antibody|Beta thionase antibody|Beta-thionase antibody|Cbs antibody|Cbs cystathionine beta-synthase antibody|CBS_HUMAN antibody|Cystathionine beta synthase antibody|Cystathionine beta-synthase antibody|EC 4.2.1.22 antibody|HIP 4 antibody|HIP4 antibody|Methylcysteine synthase antibody|MGC18856 antibody|MGC18895 antibody|MGC37300 antibody|OTTHUMP00000109416 antibody|OTTHUMP00000109418 antibody|Serine sulfhydrase antibody|Anti-CBS antibody (ab96252)

SCBT cat No: sc-133208|sc-515180|sc-133154|sc-271886|sc-67154|sc-46830|

Name

Rabbit polyclonal CBS antibody

Catalogue No.

A1427

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CBS

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 61kDa/Observed: Refer to Figures

Formulation

CBS antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CBS antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HIP4 antibody,CBS antibody

Database links

Human UniProt/Swiss-Prot:P35520

Protein names

HIP4,CBS

Protein function

Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine . Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).

Protein tissue specificity

In the adult strongly expressed in liver and pancreas, some expression in heart and brain, weak expression in lung and kidney. In the fetus, expressed in brain, liver and kidney.

Protein sequence and domain

Belongs to the cysteine synthase/cystathionine beta-synthase family.; Contains 1 CBS domain.

Protein cellular localization

Cytoplasm . Nucleus .

Background

The CBS gene encodes cystathionine beta-synthase, which catalyzes the first irreversible step of transsulfuration. The CBS enzyme is a homotetramer of 63-kD subunits and requires pyridoxal phosphate and heme for activity(PMID:11230183). CBS protein is localized in most areas of the brain, but predominantly in the cell bodies and neuronal processes of Purkinje cells and Ammon’s horn neurons(PMID:12588964). This antibody is specific to CBS.

Note

AntibodyPlus can customize CBS antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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