Rabbit polyclonal CBX4 antibody (A6221)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CBX4 antibody (A6221)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:20 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PC2 antibody, NBP16 antibody
CBX 4 antibody|CBX4 antibody|Cbx4 chromobox homolog 4 (Drosophila Pc class) antibody|CBX4_HUMAN antibody|Chromobox homolog 4 (Pc class homolog, Drosophila) antibody|Chromobox homolog 4 antibody|Chromobox protein homolog 4 antibody|E3 SUMO protein ligase CBX 4 antibody|E3 SUMO protein ligase CBX4 antibody|E3 SUMO-protein ligase CBX4 antibody|hPc 2 antibody|hPc2 antibody|NBP 16 antibody|NBP16 antibody|NS5ATP1 binding protein 16 antibody|Pc 2 antibody|Pc class 2 homolog antibody|Pc class homolog antibody|Pc class homolog Drosophila antibody|PC2 antibody|Polycomb 2 homolog antibody|Anti-CBX4 antibody (ab139815)

SCBT cat No: sc-517216|sc-19299|

Name

Rabbit polyclonal CBX4 antibody

Catalogue No.

A6221

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human CBX4

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:20 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 61kDa/Observed: Refer to Figures

Formulation

CBX4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CBX4 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PC2 antibody, NBP16 antibody

Database links

Human UniProt/Swiss-Prot:O00257

Protein names

PC2, NBP16

Protein function

E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131.; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ‘Lys-119’, rendering chromatin heritably changed in its expressibility.

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

The polyhistidine repeat may act as a targeting signal to nuclear speckles.Contains 1 chromo domain.

Protein post-translational modifications

Phosphorylated on Thr-497 by HIPK2 upon DNA damage. This phosphorylation stimulates E3 SUMO-protein ligase activity and promotes sumoylation on Lys-494, as well as sumoylation of other target proteins, such as HNRNPK.

Protein cellular localization

Nucleus . Nucleus speckle . Note: Localization to nuclear polycomb bodies is required for ZNF131 sumoylation .

Note

AntibodyPlus can customize CBX4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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