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Rabbit polyclonal CCAR1 antibody (A6334)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
CARP-1 antibody|Carp1 antibody|Ccar1 antibody|CCAR1_HUMAN antibody|Cell cycle and apoptosis regulatory protein 1 antibody|cell division cycle and apoptosis regulator 1 antibody|Cell division cycle and apoptosis regulator protein 1 antibody|Death inducer with SAP domain antibody|FLJ10590 antibody|FLJ10839 antibody|FLJ13376 antibody|FLJ20734 antibody|MGC7730 antibody|RP11-437A18.1 antibody|Anti-DIS antibody (ab70243)
SCBT cat No: sc-69263|
Rabbit polyclonal CCAR1 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human CCAR1
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 132kDa/Observed: Refer to Figures
CCAR1 antibody was tube-contained.
CCAR1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation . In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells . Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells .
|Protein tissue specificity|| |
Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors.
|Protein sequence and domain|| |
Contains 1 SAP domain.
|Protein cellular localization|| |
Cytoplasm, perinuclear region .
AntibodyPlus can customize CCAR1 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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