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Rabbit polyclonal CCNC antibody (A6545)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal CCNC antibody.
Check alternative names for the antibodyExpand
ccnc antibody|CCNC_HUMAN antibody|CycC antibody|Cyclin C antibody|Cyclin-C antibody|hSRB11 antibody|OTTHUMP00000016897 antibody|SRB11 homolog antibody|Phospho anti-Cyclin C (S275) antibody (ab78868)
SCBT cat No: sc-1061|
Rabbit polyclonal CCNC antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human CCNC
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 33kDa/Observed: Refer to figures
CCNC antibody was tube-contained.
CCNC antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
|Protein tissue specificity|| |
Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
|Protein sequence and domain|| |
Belongs to the cyclin family. Cyclin C subfamily.; Contains 1 cyclin N-terminal domain.
|Protein cellular localization|| |
The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene.
AntibodyPlus can customize CCNC antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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