Rabbit polyclonal CCNH antibody (A0995)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CCNH antibody (A0995)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:20 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CCNH antibody,CAK antibody,p34 antibody,p37 antibody
6330408H09Rik antibody|AI661354 antibody|AV102684 antibody|AW538719 antibody|CAK antibody|CAK complex subunit antibody|ccnh antibody|CCNH_HUMAN antibody|CDK activating kinase antibody|CDK activating kinase complex subunit antibody|Cyclin dependent kinase activating kinase antibody|cyclin dependent kinase activating kinase complex subunit antibody|Cyclin H antibody|Cyclin-H antibody|CyclinH antibody|MO15 associated protein antibody|MO15-associated protein antibody|p34 antibody|p36 antibody|p37 antibody|Anti-Cyclin H antibody [EPR3929] (ab92376)

SCBT cat No: sc-609|sc-855|

Name

Rabbit polyclonal CCNH antibody

Catalogue No.

A0995

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CCNH

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:20 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 38kDa/Observed: Refer to Figures

Formulation

CCNH antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CCNH antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CCNH antibody,CAK antibody,p34 antibody,p37 antibody

Database links

Human UniProt/Swiss-Prot:P51946

Protein names

CCNH,CAK,p34,p37

Protein function

Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Protein sequence and domain

Belongs to the cyclin family. Cyclin C subfamily.

Protein cellular localization

Nucleus.

Background

Cyclin H belongs to a conserved cyclin family that plays a critical role in the regulation of cell cycle dependent kinases (CDKs) necessary for cell cycle progression (1,2). In general, the activity of CDKs requires the binding of appropriate cyclins as well as phosphorylation driven by Cdk-activating kinase (CAK). Cyclin H is part of the CAK complex that includes the kinase CDK7, and an assembly factor p36/Mat1, which enhances binding between cyclin H and CDK7 and increases activity (3,4). CAK regulates progression through the cell cycle by activating cdc2, CDK2, and CDK4 kinases through phosphorylation of a critical threonine residue in the T-loop of the CDK-cyclin complexes (5,6). The CAK complex can exist either in its free form or in association with transcription factor IIH (TFIIH) which can affect its substrate specificity (7,8,9). When bound to TFIIH, CAK preferentially phosphorylates the carboxy-terminal domain of RNA polymerase II (9), providing a link between cell cycle control, transcriptional regulation, and DNA repair.

Research area

All research areas>Cell Cycle Proteins>Cyclin
(View all antibody categories related to Cell Cycle Proteins)

Note

AntibodyPlus can customize CCNH antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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