Rabbit polyclonal CD14 antibody (A5737)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CD14 antibody (A5737)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CD 14 antibody|CD_antigen=CD14 antibody|CD14 antibody|CD14 antigen antibody|CD14 molecule antibody|CD14_HUMAN antibody|LPS-R antibody|Mo2 antibody|Monocyte differentiation antigen CD14 antibody|Monocyte differentiation antigen CD14 urinary form antibody|Monocyte differentiation antigen CD14, membrane-bound form antibody|Myeloid cell specific leucine rich glycoprotein antibody|Myeloid cell-specific leucine-rich glycoprotein antibody|Anti-CD14 antibody [EPR3653] (ab133335)

SCBT cat No: sc-58951|sc-52457|sc-7328|sc-6999|sc-9150|sc-6998|sc-5749|

Name

Rabbit polyclonal CD14 antibody

Catalogue No.

A5737

Reactivity

Human

Immunogen

Recombinant protein of human CD14

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 40kDa/Observed: Refer to figures

Formulation

CD14 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CD14 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:P08571

Protein function

Coreceptor for bacterial lipopolysaccharide . In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) . Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response . Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway . Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) .

Protein tissue specificity

Detected on macrophages (at protein level) . Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.

Protein sequence and domain

The C-terminal leucine-rich repeat (LRR) region is required for responses to smooth LPS.Contains 11 LRR (leucine-rich) repeats.

Protein post-translational modifications

N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.

Protein cellular localization

Cell membrane ; Lipid-anchor, GPI-anchor . Secreted . Membrane raft . Golgi apparatus . Note: Secreted forms may arise by cleavage of the GPI anchor.

Background

The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein.

Research area

All research areas>Lymphocyte Signaling>CD14
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize CD14 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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