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Rabbit polyclonal CD14 antibody (A5737)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal CD14 antibody.
Check alternative names for the antibodyExpand
CD 14 antibody|CD_antigen=CD14 antibody|CD14 antibody|CD14 antigen antibody|CD14 molecule antibody|CD14_HUMAN antibody|LPS-R antibody|Mo2 antibody|Monocyte differentiation antigen CD14 antibody|Monocyte differentiation antigen CD14 urinary form antibody|Monocyte differentiation antigen CD14, membrane-bound form antibody|Myeloid cell specific leucine rich glycoprotein antibody|Myeloid cell-specific leucine-rich glycoprotein antibody|Anti-CD14 antibody [EPR3653] (ab133335)
SCBT cat No: sc-58951|sc-52457|sc-7328|sc-6999|sc-9150|sc-6998|sc-5749|
Rabbit polyclonal CD14 antibody
|Catalogue No.|| |
Recombinant protein of human CD14
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 40kDa/Observed: Refer to figures
CD14 antibody was tube-contained.
CD14 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
Coreceptor for bacterial lipopolysaccharide . In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) . Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response . Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway . Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) .
|Protein tissue specificity|| |
Detected on macrophages (at protein level) . Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.
|Protein sequence and domain|| |
The C-terminal leucine-rich repeat (LRR) region is required for responses to smooth LPS.Contains 11 LRR (leucine-rich) repeats.
|Protein post-translational modifications|| |
N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
|Protein cellular localization|| |
Cell membrane ; Lipid-anchor, GPI-anchor . Secreted . Membrane raft . Golgi apparatus . Note: Secreted forms may arise by cleavage of the GPI anchor.
The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein.
AntibodyPlus can customize CD14 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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