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Rabbit polyclonal CD207 antibody (A6553)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
SCBT cat No:
Rabbit polyclonal CD207 antibody
|Catalogue No.|| |
Recombinant protein of human CD207
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 36kDa/Observed: Refer to figures
CD207 antibody was tube-contained.
CD207 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
|Protein tissue specificity|| |
Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.
|Protein sequence and domain|| |
The C-type lectin domain mediates dual recognition of both sulfated and mannosylated glycans.Contains 1 C-type lectin domain.
|Protein cellular localization|| |
Membrane ; Single-pass type II membrane protein . Note: Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity.
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|Product type|| |
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