Rabbit polyclonal CD209 antibody (A1466)

$69.00$259.00

Reactivity: Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CD209 antibody (A1466)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:200 – 1:500

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CDSIGN antibody, CLEC4L antibody, DC-SIGN antibody, DC-SIGN1 antibody
C type lectin domain family 4 member L antibody|C-type lectin domain family 4 member L antibody|CD 209 antibody|CD209 antibody|CD209 antigen antibody|CD209 antigen-like protein A antibody|CD209 molecule antibody|CD209_HUMAN antibody|Cd209a antibody|CDSIGN antibody|CIRE antibody|CLEC4L antibody|DC SIGN antibody|DC SIGN1 antibody|DC-SIGN antibody|DC-SIGN1 antibody|DCSIGN antibody|Dendritic cell specific ICAM 3 grabbing nonintegrin 1 antibody|Dendritic cell specific ICAM3 grabbing nonintegrin 1 antibody|Dendritic cell-specific ICAM-3-grabbing non-integrin 1 antibody|Dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin antibody|Dengue fever, protection against, included antibody|Dentritic Cell Specific ICAM3 Grabbing Nonintegrin antibody|HIV GP120 Binding Protein antibody|MGC129965 antibody|MGC130443 antibody|SIGN-R1 antibody|SIGNR5 antibody|Anti-DC-SIGN antibody [5D7] (ab59192)

SCBT cat No: sc-23926|sc-53580|sc-53967|sc-11038|sc-65740|sc-52660|sc-59157|sc-32021|sc-32022|sc-53965|sc-53966|

Name

Rabbit polyclonal CD209 antibody

Catalogue No.

A1466

Reactivity

Mouse, Rat

Immunogen

Recombinant protein of human CD209

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:200 – 1:500

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 46kDa/Observed: Refer to Figures

Formulation

CD209 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CD209 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CDSIGN antibody, CLEC4L antibody, DC-SIGN antibody, DC-SIGN1 antibody

Database links

Human UniProt/Swiss-Prot:Q9NNX6

Protein names

CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1

Protein function

Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response.; On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.; (Microbial infection) Acts as an attachment receptor for HIV-1 and HIV-2 . Acts as an attachment receptor for ebolavirus . Acts as an attachment receptor for cytomegalovirus . Acts as an attachment receptor for HCV . Acts as an attachment receptor for dengue virus . Acts as an attachment receptor for measles virus . Acts as an attachment receptor for herpes simplex virus 1 . Acts as an attachment receptor for Influenzavirus A . Acts as an attachment receptor for SARS coronavirus . Acts as an attachment receptor for Japanese encephalitis virus . Acts as an attachment receptor for Lassa virus . Acts as an attachment receptor for marburg virusn . Acts as an attachment receptor for Respiratory syncytial virus . Acts as an attachment receptor for Rift valley fever virus and uukuniemi virus . Acts as an attachment receptor for west-nile virus . Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens, including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA . Recognition of M.tuberculosis by dendritic cells occurs partially via this molecule .

Protein tissue specificity

Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes.

Protein sequence and domain

The tandem repeat domain, also called neck domain, mediates oligomerization.Contains 1 C-type lectin domain.

Protein cellular localization

Isoform 1: Cell membrane ; Single-pass type II membrane protein .; Isoform 2: Cell membrane ; Single-pass type II membrane protein .; Isoform 3: Cell membrane ; Single-pass type II membrane protein .; Isoform 4: Cell membrane ; Single-pass type II membrane protein .; Isoform 5: Cell membrane ; Single-pass type II membrane protein .; Isoform 6: Secreted .; Isoform 7: Secreted .; Isoform 8: Secreted .; Isoform 9: Secreted .; Isoform 10: Secreted .; Isoform 11: Secreted .; Isoform 12: Secreted .

Background

This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

Research area

All research areas>Lymphocyte Signaling>CD209
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize CD209 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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