Rabbit polyclonal CD3E antibody (A1753)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CD3E antibody (A1753)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CD3E antibody.

Alternative names:

Check alternative names for the antibody

Expand

CD3epsilon antibody, FLJ18683 antibody, T3E antibody, TCRE antibody
CD3 epsilon antibody|CD3e antibody|CD3e antigen epsilon polypeptide (TiT3 complex) antibody|CD3E antigen epsilon polypeptide antibody|CD3E antigen, epsilon subunit antibody|CD3e molecule epsilon antibody|CD3e molecule, epsilon (CD3 TCR complex) antibody|CD3e molecule, epsilon (CD3-TCR complex) antibody|CD3E_HUMAN antibody|IMD18 antibody|T cell antigen receptor complex epsilon subunit of T3 antibody|T cell surface antigen T3/Leu 4 epsilon chain antibody|T cell surface glycoprotein CD3 epsilon chain antibody|T-cell surface antigen T3/Leu-4 epsilon chain antibody|T-cell surface glycoprotein CD3 epsilon chain antibody|T3E antibody|TCRE antibody|Anti-CD3 epsilon antibody [EP449E] (ab52959)

SCBT cat No: sc-20047|sc-1128|sc-137137|sc-30160|sc-1129|sc-26429|sc-26431|sc-18871|sc-1174|

Name

Rabbit polyclonal CD3E antibody

Catalogue No.

A1753

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CD3E

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 23kDa/Observed: Refer to Figures

Formulation

CD3E antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CD3E antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CD3epsilon antibody, FLJ18683 antibody, T3E antibody, TCRE antibody

Database links

Human UniProt/Swiss-Prot:P07766

Protein names

CD3epsilon, FLJ18683, T3E, TCRE

Protein function

The CD3 complex mediates signal transduction, resulting in T-cell activation and proliferation. Required for normal immune responses .

Protein sequence and domain

Contains 1 Ig-like (immunoglobulin-like) domain.; Contains 1 ITAM domain.

Protein cellular localization

Cell membrane ; Single-pass type I membrane protein .

Background

When T cells encounter antigens via the T cell receptor (TCR), information about the quantity and quality of antigens is relayed to the intracellular signal transduction machinery (1). This activation process depends mainly on CD3 (Cluster of Differentiation 3), a multiunit protein complex that directly associates with the TCR. CD3 is composed of four polypeptides: zeta, gamma, epsilon and delta. Each of these polypeptides contains at least one immunoreceptor tyrosine-based activation motif (ITAM) (2). Engagement of TCR complex with foreign antigens induces tyrosine phosphorylation in the ITAM motifs and phosphorylated ITAMs function as docking sites for signaling molecules such as ZAP-70 and p85 subunit of PI-3 kinase (3,4). TCR ligation also induces a conformational change in CD3epsilon, such that a proline-region is exposed and then associates with the adapter protein Nck (5).

Research area

All research areas>Lymphocyte Signaling>CD3
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize CD3E antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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