Rabbit polyclonal CD4 antibody (A1549)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CD4 antibody (A1549)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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CD4mut antibody
CD 4 antibody|CD4 (L3T4) antibody|CD4 antibody|CD4 antigen (p55) antibody|CD4 antigen antibody|CD4 molecule antibody|CD4 receptor antibody|CD4+ Lymphocyte deficiency, included antibody|CD4_HUMAN antibody|CD4mut antibody|L3T4 antibody|Leu3 antibody|Ly-4 antibody|Lymphocyte antigen CD4 antibody|MGC165891 antibody|OTTHUMP00000238897 antibody|p55 antibody|T cell antigen T4 antibody|T cell antigen T4/LEU3 antibody|T cell differentiation antigen L3T4 antibody|T cell OKT4 deficiency, included antibody|T cell surface antigen T4/Leu 3 antibody|T cell surface antigen T4/Leu3 antibody|T cell surface glycoprotein CD4 antibody|T-cell surface antigen T4/Leu-3 antibody|T-cell surface glycoprotein CD4 antibody|W3/25 antibody|W3/25 antigen antibody|Anti-CD4 antibody [EPR6855] (ab133616)

SCBT cat No: sc-70660|sc-59031|sc-1176|sc-59032|sc-70674|sc-70670|sc-70659|sc-514571|sc-32811|sc-59034|sc-514746|sc-1140|sc-51544|sc-13573|sc-19642|sc-7219|sc-51545|sc-51547|sc-19641|sc-53042|sc-52385|sc-19643|

Name

Rabbit polyclonal CD4 antibody

Catalogue No.

A1549

Reactivity

Human, Mouse

Immunogen

A synthetic peptide of human CD4

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 55kDa/Observed: Refer to Figures

Formulation

CD4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CD4 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CD4mut antibody

Database links

Human UniProt/Swiss-Prot:P01730

Protein names

CD4mut

Protein function

Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.; (Microbial infection) Acts as a receptor for human immunodeficiency virus-1 . Down-regulated by HIV-1 Vpu . Acts as a receptor for Human Herpes virus 7/HHV-7 .

Protein sequence and domain

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.; Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Protein post-translational modifications

Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.

Protein cellular localization

Cell membrane ; Single-pass type I membrane protein . Note: Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.

Background

Cluster of Differentiation 4 (CD4) is a glycoprotein composed of an amino-terminal extracellular domain (four domains: D1-D4 with Ig-like structures), a transmembrane part and a short cytoplasmic tail. CD4 is expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages and dendritic cells, and plays an important role in the development and activation of T cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the D1 domain of CD4 interacts with the beta2-domain of the MHC class II molecule. CD4 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell and recruits the tyrosine kinase Lck, which is essential for T cell activation (1).

Research area

All research areas>Lymphocyte Signaling>CD4
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize CD4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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