Rabbit polyclonal CD40LG antibody (A0327)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal CD40LG antibody (A0327)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CD40LG antibody.

Alternative names:

Check alternative names for the antibody

Expand

CD40LG antibody,CD154 antibody,CD40L antibody,HIGM1 antibody,IGM antibody,IMD3 antibody,T-BAM antibody,TNFSF5 antibody,TRAP antibody,gp39 antibody,hCD40L antibody
CD 40L antibody|TNFSF5 antibody|TrAP antibody|Tumor necrosis factor (ligand) superfamily member 5 antibody|Tumor necrosis factor ligand superfamily member 5 antibody|Anti-CD40L antibody (ab2391)

SCBT cat No: sc-74447|sc-978|sc-1593|sc-74448|sc-374635|sc-9097|sc-1594|sc-19985|

Name

Rabbit polyclonal CD40LG antibody

Catalogue No.

A0327

Reactivity

Human

Immunogen

Recombinant protein of human CD40LG

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 29kDa/Observed: Refer to Figures

Formulation

CD40LG antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CD40LG antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CD40LG antibody,CD154 antibody,CD40L antibody,HIGM1 antibody,IGM antibody,IMD3 antibody,T-BAM antibody,TNFSF5 antibody,TRAP antibody,gp39 antibody,hCD40L antibody

Database links

Human UniProt/Swiss-Prot:P29965

Protein names

CD40LG,CD154,CD40L,HIGM1,IGM,IMD3,T-BAM,TNFSF5,TRAP,gp39,hCD40L

Protein function

Cytokine that binds to CD40/TNFRSF5 . Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation . Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28 . Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching (By similarity).; Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.

Protein tissue specificity

Specifically expressed on activated CD4+ T-lymphocytes.

Protein sequence and domain

Belongs to the tumor necrosis factor family.

Protein post-translational modifications

The soluble form derives from the membrane form by proteolytic processing.; N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40.; Not O-glycosylated.

Protein cellular localization

Cell membrane ; Single-pass type II membrane protein . Cell surface .; CD40 ligand, soluble form: Secreted .

Background

CD40 Ligand (CD40L), a member of the TNF superfamily of ligands, is expressed as either a membrane-bound or soluble homotrimer (1). Both membrane-bound and soluble forms of CD40L have biological activity (1,2). CD40L is expressed primarily on activated T cells; however, mast cells, basophils, and NK cells may also express CD40L (1). CD40L functions as an important T cell co-stimulatory molecule and enhances T-dependent B cell responses (1,2). CD40L binds CD40, which is a receptor expressed on B cells, dendritic cells, and macrophages (1). Binding of CD40L to CD40 leads to the recruitment of TRAF proteins (TRAFs 2,3,5, and 6) resulting in the activation of the JNK and NF-kappaB pathways (1,2).

Note

AntibodyPlus can customize CD40LG antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!