Rabbit polyclonal CD40LG antibody (A0327)


Reactivity: Human
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CD40LG antibody (A0327)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody


CD40LG antibody,CD154 antibody,CD40L antibody,HIGM1 antibody,IGM antibody,IMD3 antibody,T-BAM antibody,TNFSF5 antibody,TRAP antibody,gp39 antibody,hCD40L antibody
CD 40L antibody|TNFSF5 antibody|TrAP antibody|Tumor necrosis factor (ligand) superfamily member 5 antibody|Tumor necrosis factor ligand superfamily member 5 antibody|Anti-CD40L antibody (ab2391)

SCBT cat No: sc-74447|sc-978|sc-1593|sc-74448|sc-374635|sc-9097|sc-1594|sc-19985|


Rabbit polyclonal CD40LG antibody

Catalogue No.





Recombinant protein of human CD40LG





Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200







Molecular weight

Predicted: 29kDa/Observed: Refer to Figures


CD40LG antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.


CD40LG antibody was purified using affinity purification.


Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CD40LG antibody,CD154 antibody,CD40L antibody,HIGM1 antibody,IGM antibody,IMD3 antibody,T-BAM antibody,TNFSF5 antibody,TRAP antibody,gp39 antibody,hCD40L antibody

Database links

Human UniProt/Swiss-Prot:P29965

Protein names


Protein function

Cytokine that binds to CD40/TNFRSF5 . Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation . Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28 . Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching (By similarity).; Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.

Protein tissue specificity

Specifically expressed on activated CD4+ T-lymphocytes.

Protein sequence and domain

Belongs to the tumor necrosis factor family.

Protein post-translational modifications

The soluble form derives from the membrane form by proteolytic processing.; N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40.; Not O-glycosylated.

Protein cellular localization

Cell membrane ; Single-pass type II membrane protein . Cell surface .; CD40 ligand, soluble form: Secreted .


CD40 Ligand (CD40L), a member of the TNF superfamily of ligands, is expressed as either a membrane-bound or soluble homotrimer (1). Both membrane-bound and soluble forms of CD40L have biological activity (1,2). CD40L is expressed primarily on activated T cells; however, mast cells, basophils, and NK cells may also express CD40L (1). CD40L functions as an important T cell co-stimulatory molecule and enhances T-dependent B cell responses (1,2). CD40L binds CD40, which is a receptor expressed on B cells, dendritic cells, and macrophages (1). Binding of CD40L to CD40 leads to the recruitment of TRAF proteins (TRAFs 2,3,5, and 6) resulting in the activation of the JNK and NF-kappaB pathways (1,2).


AntibodyPlus can customize CD40LG antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody


ABclonal Inc.


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