Rabbit polyclonal CD59 antibody (A1689)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CD59 antibody (A1689)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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1F5 antibody, EJ16 antibody, EJ30 antibody, EL32 antibody, G344 antibody, MIN1 antibody, MIN2 antibody, MIN3 antibody, MIRL antibody, HRF20 antibody, MACIF antibody, MEM43 antibody, MIC11 antibody, MSK21 antibody, 16.3A5 antibody, HRF-20 antibody, MAC-IP antibody, p18-20 antibody
16.3A5 antibody|1F5 antibody|1F5 antigen antibody|20 kDa homologous restriction factor antibody|CD 59 antibody|CD_antigen=CD59 antibody|CD59 antibody|CD59 antigen antibody|CD59 antigen complement regulatory protein antibody|CD59 antigen p18 20 antibody|CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344) antibody|CD59 glycoprotein antibody|CD59 molecule antibody|CD59 molecule complement regulatory protein antibody|CD59_HUMAN antibody|Cd59a antibody|Complement regulatory protein antibody|EJ16 antibody|EJ30 antibody|EL32 antibody|FLJ38134 antibody|FLJ92039 antibody|G344 antibody|HRF 20 antibody|HRF-20 antibody|HRF20 antibody|Human leukocyte antigen MIC11 antibody|Ly 6 like protein antibody|Lymphocytic antigen CD59/MEM43 antibody|MAC inhibitory protein antibody|MAC IP antibody|MAC-inhibitory protein antibody|MAC-IP antibody|MACIF antibody|MACIP antibody|MEM43 antibody|MEM43 antigen antibody|Membrane attack complex (MAC) inhibition factor antibody|Membrane attack complex inhibition factor antibody|Membrane inhibitor of reactive lysis antibody|MGC2354 antibody|MIC11 antibody|MIN1 antibody|MIN2 antibody|MIN3 antibody|MIRL antibody|MSK21 antibody|p18 20 antibody|Protectin antibody|Surface antigen recognized by monoclonal antibody 16.3A5 antibody|T cell activating protein antibody|Anti-CD59 antibody [MEM-43] (ab9182)

SCBT cat No: sc-133171|sc-7076|sc-28843|sc-133170|sc-28805|sc-7077|

Name

Rabbit polyclonal CD59 antibody

Catalogue No.

A1689

Reactivity

Human, Mouse

Immunogen

Recombinant Protein of human CD59

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 19kDa/Observed: Refer to Figures

Formulation

CD59 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CD59 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

1F5 antibody, EJ16 antibody, EJ30 antibody, EL32 antibody, G344 antibody, MIN1 antibody, MIN2 antibody, MIN3 antibody, MIRL antibody, HRF20 antibody, MACIF antibody, MEM43 antibody, MIC11 antibody, MSK21 antibody, 16.3A5 antibody, HRF-20 antibody, MAC-IP antibody, p18-20 antibody

Database links

Human UniProt/Swiss-Prot:P13987

Protein names

1F5, EJ16, EJ30, EL32, G344, MIN1, MIN2, MIN3, MIRL, HRF20, MACIF, MEM43, MIC11, MSK21, 16.3A5, HRF-20, MAC-IP, p18-20

Protein function

Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.; The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.

Protein sequence and domain

Contains 1 UPAR/Ly6 domain.

Protein post-translational modifications

N- and O-glycosylated. The N-glycosylation mainly consists of a family of biantennary complex-type structures with and without lactosamine extensions and outer arm fucose residues. Also significant amounts of triantennary complexes (22%). Variable sialylation also present in the Asn-43 oligosaccharide. The predominant O-glycans are mono-sialylated forms of the disaccharide, Gal-beta-1,3GalNAc, and their sites of attachment are probably on Thr-76 and Thr-77. The GPI-anchor of soluble urinary CD59 has no inositol-associated phospholipid, but is composed of seven different GPI-anchor variants of one or more monosaccharide units. Major variants contain sialic acid, mannose and glucosamine. Sialic acid linked to an N-acetylhexosamine-galactose arm is present in two variants.; Glycated. Glycation is found in diabetic subjects, but only at minimal levels in nondiabetic subjects. Glycated CD59 lacks MAC-inhibitory function and confers to vascular complications of diabetes.

Protein cellular localization

Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note: Soluble form found in a number of tissues.

Background

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Research area

All research areas>Lymphocyte Signaling>CD59
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize CD59 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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