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Rabbit polyclonal CD6 antibody (A8107)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:500 – 1:2000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
CD_antigen=CD6 antibody|CD6 antibody|CD6 antigen Tp120 antibody|CD6 molecule antibody|CD6_HUMAN antibody|FLJ44171 antibody|OX52 antibody|T cell differentiation antigen CD6 antibody|T-cell differentiation antigen CD6 antibody|T12 antibody|TP120 antibody|Anti-CD6 antibody [EPR4057] (ab109217)
SCBT cat No: sc-7074|sc-373753|sc-20921|sc-373947|sc-7320|sc-65249|
Rabbit polyclonal CD6 antibody
|Catalogue No.|| |
Recombinant protein of human CD6
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 72kDa/Observed: Refer to figures
CD6 antibody was tube-contained.
CD6 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 . Contributes to signaling cascades triggered by activation of the TCR/CD3 complex . Functions as costimulatory molecule; promotes T-cell activation and proliferation . Contributes to the formation and maturation of the immunological synapse . Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria . LPS binding leads to the activation of signaling cascades and down-stream MAP kinases . Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS .
|Protein tissue specificity|| |
Detected on thymocytes . Detected on peripheral blood T-cells . Detected on natural killer (NK) cells . Soluble CD6 is detected in blood serum (at protein level) . Detected in spleen, thymus, appendix, lymph node and peripheral blood leukocytes . Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.
|Protein sequence and domain|| |
Contains 3 SRCR domains.
|Protein post-translational modifications|| |
After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues.; Glycosylated.
|Protein cellular localization|| |
Cell membrane ; Single-pass type I membrane protein . Note: Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells . Colocalizes with the TCR/CD3 complex at the immunological synapse .; Soluble CD6: Secreted . Note: The origins of the secreted form are not clear, but it might be created by proteolytic shedding of the ectodomain.
This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene.
AntibodyPlus can customize CD6 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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