Rabbit polyclonal CD6 antibody (A8107)

$69.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CD6 antibody (A8107)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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TP120 antibody
CD_antigen=CD6 antibody|CD6 antibody|CD6 antigen Tp120 antibody|CD6 molecule antibody|CD6_HUMAN antibody|FLJ44171 antibody|OX52 antibody|T cell differentiation antigen CD6 antibody|T-cell differentiation antigen CD6 antibody|T12 antibody|TP120 antibody|Anti-CD6 antibody [EPR4057] (ab109217)

SCBT cat No: sc-7074|sc-373753|sc-20921|sc-373947|sc-7320|sc-65249|

Name

Rabbit polyclonal CD6 antibody

Catalogue No.

A8107

Reactivity

Human

Immunogen

Recombinant protein of human CD6

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 72kDa/Observed: Refer to figures

Formulation

CD6 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CD6 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

TP120 antibody

Database links

Human UniProt/Swiss-Prot:P30203

Protein names

TP120

Protein function

Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 . Contributes to signaling cascades triggered by activation of the TCR/CD3 complex . Functions as costimulatory molecule; promotes T-cell activation and proliferation . Contributes to the formation and maturation of the immunological synapse . Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria . LPS binding leads to the activation of signaling cascades and down-stream MAP kinases . Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS .

Protein tissue specificity

Detected on thymocytes . Detected on peripheral blood T-cells . Detected on natural killer (NK) cells . Soluble CD6 is detected in blood serum (at protein level) . Detected in spleen, thymus, appendix, lymph node and peripheral blood leukocytes . Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.

Protein sequence and domain

Contains 3 SRCR domains.

Protein post-translational modifications

After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues.; Glycosylated.

Protein cellular localization

Cell membrane ; Single-pass type I membrane protein . Note: Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells . Colocalizes with the TCR/CD3 complex at the immunological synapse .; Soluble CD6: Secreted . Note: The origins of the secreted form are not clear, but it might be created by proteolytic shedding of the ectodomain.

Background

This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Lymphocyte Signaling>CD6
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize CD6 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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