Rabbit polyclonal CD74 antibody (A5667)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CD74 antibody (A5667)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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II antibody, DHLAG antibody, HLADG antibody, Ia-GAMMA antibody
CD 74 antibody|CD74 antibody|CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) antibody|CD74 antigen antibody|CD74 molecule antibody|CD74 molecule, major histocompatibility complex, class II invariant chain antibody|CLIP antibody|DHLAG antibody|Gamma chain of class II antigens antibody|HG2A_HUMAN antibody|HLA class II histocompatibility antigen gamma chain antibody|HLA DR antigens associated invariant chain antibody|HLA DR gamma antibody|HLA-DR antigens-associated invariant chain antibody|HLA-DR-gamma antibody|HLADG antibody|HLADR antigens associated invariant chain antibody|Ia antigen associated invariant chain antibody|Ia antigen-associated invariant chain antibody|Ia associated invariant chain antibody|Ia gamma antibody|Ii antibody|Invariant polypeptide of major histocompatibility complex class II antigen associated antibody|la-gamma antibody|Major histocompatibility complex class II invariant chain antibody|MHC HLA DR gamma chain antibody|MHC HLA-DR gamma chain antibody|p33 antibody|p35 antibody|Protein 41 antibody|Anti-CD74 antibody [LN2] (ab9514)

SCBT cat No: sc-70781|sc-166047|sc-20062|sc-5438|sc-137217|sc-20082|sc-19627|sc-6262|sc-65272|sc-53060|sc-53062|sc-47742|

Name

Rabbit polyclonal CD74 antibody

Catalogue No.

A5667

Reactivity

Human

Immunogen

Recombinant protein of human CD74

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 33kDa/Observed: Refer to Figures

Formulation

CD74 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CD74 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

II antibody, DHLAG antibody, HLADG antibody, Ia-GAMMA antibody

Database links

Human UniProt/Swiss-Prot:P04233

Protein names

II, DHLAG, HLADG, Ia-GAMMA

Protein function

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

Protein sequence and domain

Contains 1 thyroglobulin type-1 domain.

Protein post-translational modifications

N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.

Protein cellular localization

Cell membrane ; Single-pass type II membrane protein . Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note: Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.

Background

The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Research area

All research areas>Lymphocyte Signaling>CD74
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize CD74 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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