Rabbit polyclonal CD84 antibody (A6433)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CD84 antibody (A6433)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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LY9B antibody, hCD84 antibody, mCD84 antibody, SLAMF5 antibody
CD_antigen=CD84 antibody|CD84 antibody|CD84 antigen antibody|CD84 molecule antibody|CDw84 antibody|Cell surface antigen MAX.3 antibody|hCD84 antibody|Hly9 beta antibody|Hly9-beta antibody|Leucocyte differentiation antigen CD84 antibody|Leukocyte Antigen antibody|Leukocyte antigen CD84 antibody|Leukocyte differentiation antigen antibody|Leukocyte differentiation antigen CD84 antibody|LY9B antibody|mCD84 antibody|Signaling lymphocytic activation molecule 5 antibody|SLAF5_HUMAN antibody|SLAM family member 5 antibody|SLAMF5 antibody|Anti-CD84 antibody [EPR8325] (ab131256)

SCBT cat No: sc-70809|sc-23899|sc-70810|sc-59137|sc-398321|sc-32952|

Name

Rabbit polyclonal CD84 antibody

Catalogue No.

A6433

Reactivity

Human

Immunogen

Recombinant protein of human CD84

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 38kDa/Observed: Refer to Figures

Formulation

CD84 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CD84 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

LY9B antibody, hCD84 antibody, mCD84 antibody, SLAMF5 antibody

Database links

Human UniProt/Swiss-Prot:Q9UIB8

Protein names

LY9B, hCD84, mCD84, SLAMF5

Protein function

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 . In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity).

Protein tissue specificity

Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells. Expressed in mast cells.

Protein sequence and domain

The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containingbinding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A ‘three-pronged’ mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).Contains 1 Ig-like C2-type (immunoglobulin-like) domain.; Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Protein post-translational modifications

Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist monoclonal antibody. The association with SH2D1A is dependent of tyrosine phosphorylation of its cytoplasmic domain. Phosphorylated on Tyr-296 and Tyr-316 following platelet aggregation. Phosphorylated on tyrosine residues upon high affinity immunoglobulin epsilon receptor aggregation in mast cells.; N-glycosylated.

Protein cellular localization

Cell membrane ; Single-pass type I membrane protein .

Background

This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants.

Research area

All research areas>Lymphocyte Signaling>CD84
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize CD84 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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