Rabbit polyclonal CD8B antibody (A3286)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CD8B antibody (A3286)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:200 – 1:500

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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LY3 antibody, P37 antibody, LEU2 antibody, LYT3 antibody, CD8B1 antibody
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SCBT cat No:

Name

Rabbit polyclonal CD8B antibody

Catalogue No.

A3286

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CD8B

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:200 – 1:500

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 27kDa/Observed: Refer to Figures

Formulation

CD8B antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CD8B antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

LY3 antibody, P37 antibody, LEU2 antibody, LYT3 antibody, CD8B1 antibody

Database links

Human UniProt/Swiss-Prot:P10966

Protein names

LY3, P37, LEU2, LYT3, CD8B1

Protein function

Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.

Protein tissue specificity

Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells.

Protein sequence and domain

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Protein post-translational modifications

Phosphorylated as a consequence of T-cell activation.

Protein cellular localization

Isoform 1: Cell membrane ; Single-pass type I membrane protein .; Isoform 2: Cell membrane ; Single-pass type I membrane protein .; Isoform 3: Secreted .; Isoform 4: Cell membrane ; Single-pass type I membrane protein .; Isoform 5: Cell membrane ; Single-pass type I membrane protein .; Isoform 6: Secreted .; Isoform 7: Secreted .; Isoform 8: Secreted .

Background

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified.

Research area

All research areas>Lymphocyte Signaling>CD8
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize CD8B antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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