Rabbit polyclonal CDC16 antibody (A7197)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CDC16 antibody (A7197)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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APC6 antibody, CUT9 antibody, ANAPC6 antibody
ANAPC6 antibody|Anaphase promoting complex subunit 6 antibody|Anaphase-promoting complex subunit 6 antibody|Apc 6 antibody|APC6 antibody|CDC 16 antibody|CDC16 (cell division cycle 16 S. cerevisiae homolog) antibody|Cdc16 antibody|CDC16 homolog antibody|CDC16 protein antibody|CDC16_HUMAN antibody|CDC16Hs antibody|Cell division cycle 16 antibody|Cell division cycle 16 homolog antibody|Cell division cycle protein 16 homolog antibody|CUT9 antibody|Cyclosome subunit 6 antibody|Anti-Apc6 antibody [EPR11168] (ab169536)

SCBT cat No: sc-376091|sc-365636|sc-365788|sc-5615|

Name

Rabbit polyclonal CDC16 antibody

Catalogue No.

A7197

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CDC16

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 72kDa/Observed: Refer to figures

Formulation

CDC16 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CDC16 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

APC6 antibody, CUT9 antibody, ANAPC6 antibody

Database links

Human UniProt/Swiss-Prot:Q13042

Protein names

APC6, CUT9, ANAPC6

Protein function

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of ‘Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ‘Lys-48’- and ‘Lys-63’-linked polyubiquitin chains.

Protein sequence and domain

TPR repeats 1-7 mediate homodimerization, while the C-terminal TPR repeats bind to CDC26, burying its hydrophobic N-terminus.Belongs to the APC6/CDC16 family.; Contains 14 TPR repeats.

Protein post-translational modifications

Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis.

Protein cellular localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Note: Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.

Background

This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ubiquitin ligase. The APC complex is a cyclin degradation system that governs exit from mitosis. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein and two other APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain that may be involved in protein-protein interaction. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Research area

All research areas>Cell Cycle Proteins>Cdc
(View all antibody categories related to Cell Cycle Proteins)

Note

AntibodyPlus can customize CDC16 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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