Rabbit polyclonal CDCP1 antibody (A8254)

$69.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CDCP1 antibody (A8254)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CDCP1 antibody.

Alternative names:

Check alternative names for the antibody

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CD318 antibody, TRASK antibody, SIMA135 antibody
9030022E12Rik antibody|AA409659 antibody|CD 318 antibody|CD_antigen=CD318 antibody|CD318 antibody|CD318 antigen antibody|CDCP 1 antibody|Cdcp1 antibody|CDCP1_HUMAN antibody|CUB domain containing protein 1 antibody|CUB domain-containing protein 1 antibody|E030027H19Rik antibody|FLJ13772 antibody|FLJ22375 antibody|FLJ22969 antibody|Membrane glycoprotein gp140 antibody|MGC31813 antibody|OTTHUMP00000164120 antibody|OTTHUMP00000209568 antibody|RGD1305578 antibody|SIMA 135 antibody|SIMA135 antibody|Subtractive immunization M plus HEp3 associated 135 kDa protein antibody|Subtractive immunization M plus HEp3-associated 135 kDa protein antibody|Transmembrane and associated with src kinases antibody|TRASK antibody|Anti-CDCP1 antibody (ab1377)

SCBT cat No: sc-515545|sc-32844|sc-292398|

Name

Rabbit polyclonal CDCP1 antibody

Catalogue No.

A8254

Reactivity

Human

Immunogen

Recombinant protein of human CDCP1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 93kDa/Observed: Refer to figures

Formulation

CDCP1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CDCP1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CD318 antibody, TRASK antibody, SIMA135 antibody

Database links

Human UniProt/Swiss-Prot:Q9H5V8

Protein names

CD318, TRASK, SIMA135

Protein function

May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.

Protein tissue specificity

Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells.

Protein sequence and domain

Contains 1 CUB domain.

Protein post-translational modifications

Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5.; N-glycosylated.; A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its N-terminal side. Converted to p80 by plasmin, a trypsin-like protease.

Protein cellular localization

Isoform 1: Cell membrane ; Single-pass membrane protein . Note: Shedding may also lead to a soluble peptide.; Isoform 3: Secreted.

Background

This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene.

Note

AntibodyPlus can customize CDCP1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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