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Rabbit polyclonal CDK6 antibody (A3165)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:100
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
CDK 6 antibody|CDK6 antibody|CDK6_HUMAN antibody|Cell division protein kinase 6 antibody|Crk 2 antibody|Crk2 antibody|Cyclin dependent kinase 6 antibody|Cyclin-dependent kinase 6 antibody|MGC59692 antibody|p40 antibody|PLSTIRE antibody|Serine/threonine protein kinase PLSTIRE antibody|Serine/threonine-protein kinase PLSTIRE antibody|STQTL11 antibody|Anti-Cdk6 antibody [EPR4515] (ab124821) KO Validated
SCBT cat No: sc-7961|sc-177|sc-53638|sc-56282|sc-390493|sc-271364|sc-7181|sc-7180|sc-32501|sc-56362|sc-136386|
Rabbit polyclonal CDK6 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human CDK6
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 37kDa/Observed: Refer to Figures
CDK6 antibody was tube-contained.
CDK6 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases .
|Protein tissue specificity|| |
Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in differentiating cells.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.; Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Thr-177 phosphorylation and Tyr-24 dephosphorylation promotes kinase activity.
|Protein cellular localization|| |
Cytoplasm. Nucleus. Cell projection, ruffle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Note: Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus. Localized to the cytosol of neurons and showed prominent staining around either side of the nucleus (By similarity). Present in the cytosol and in the nucleus in interphase cells and at the centrosome during mitosis from prophase to telophase .
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.
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|Product type|| |
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