Rabbit polyclonal CDKN1C antibody (A2060)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CDKN1C antibody (A2060)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CDKN1C antibody.

Alternative names:

Check alternative names for the antibody

Expand

BWCR antibody, BWS antibody, KIP2 antibody, WBS antibody, p57 antibody
Beckwith Wiedemann syndrome antibody|BWCR antibody|BWS antibody|CDKI antibody|CDKN 1C antibody|CDKN1C antibody|CDN1C_HUMAN antibody|Cyclin dependent kinase inhibitor 1C antibody|Cyclin dependent kinase inhibitor p57 antibody|Cyclin-dependent kinase inhibitor 1C antibody|Cyclin-dependent kinase inhibitor p57 antibody|KIP 2 antibody|KIP2 antibody|p57 antibody|p57 Kip 2 antibody|p57KIP2 antibody|WBS antibody|Anti-p57 Kip2 antibody [EP2515Y] (ab75974)

SCBT cat No: sc-1037|

Name

Rabbit polyclonal CDKN1C antibody

Catalogue No.

A2060

Reactivity

Human

Immunogen

A synthetic peptide of human CDKN1C

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 32kDa/Observed: Refer to Figures

Formulation

CDKN1C antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CDKN1C antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

BWCR antibody, BWS antibody, KIP2 antibody, WBS antibody, p57 antibody

Database links

Human UniProt/Swiss-Prot:P49918

Protein names

BWCR, BWS, KIP2, WBS, p57

Protein function

Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.

Protein tissue specificity

Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.

Protein sequence and domain

Belongs to the CDI family.

Protein cellular localization

Nucleus .

Background

p27 Kip1 is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. Like its relatives, p57 Kip2 and p21 Waf1/Cip1, the ability to enforce the G1 restriction point is derived from its inhibitory binding to CDK2/cyclin E and other CDK/cyclin complexes. Expression levels of p27 are upregulated in quiescent cells and in cells treated with cAMP or other negative cell cycle regulators. Downregulation of p27 can be induced by treatment with interleukin-2 or other mitogens; this involves phosphorylation of p27 and its degradation by the ubiquitin-proteasome pathway (1-4).p57 Kip2 (Cyclin-dependent kinase inhibitor 1C) functions as a tumor suppressor. Mutations of p57 Kip2 have been associated with numerous human malignancies as well as Beckwith–Wiedemann syndrome (BWS), characterized by an increased risk of childhood cancer. The amino-terminal CDK inhibitory domain, common to the family, binds to and inhibits CDK/cyclin complexes and restricts cell cycle progression (5). The unique central region of p57 Kip2 interactes with LIMK-1, a downstream effector of the Rho family of GTPases. By sequestering LIMK-1 in the nucleus, p57 Kip2 disrupts actin dynamics within cells and may be linked to its essential role in embryonic development (6). In addition, the carboxyl-terminal QT domain of p57KIP2 binds to and inhibits JNK/SAPK activity regulating cellular apoptosis and differentiation (7). Expression levels of human p57 Kip2 are more restricted then other CDK inhibitors (8) and are controlled by ubiquitination/degradation via the Skp1/Cul1/F-box-type E3 ubiquitin ligase complex SCF-Skp2. This effect is dependent on Thr310 (9). A similar threonine phosphorylation site in p27 Kip1, Thr187, has also been shown to regulate protein stability (10).

Research area

All research areas>Cell Cycle Proteins>p57
(View all antibody categories related to Cell Cycle Proteins)

Note

AntibodyPlus can customize CDKN1C antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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