Rabbit polyclonal CEACAM3 antibody (A2589)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CEACAM3 antibody (A2589)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CEACAM3 antibody.

Alternative names:

Check alternative names for the antibody

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CEA antibody, CGM1 antibody, W264 antibody, W282 antibody, CD66D antibody
carcinoembryonic antibody|cd66 d antibody|CD66d antibody|CD66d antigen antibody|CEA antibody|CEACAM 3 antibody|CEACAM-3 antibody|Ceacam3 antibody|CEAM 3 antibody|CEAM-3 antibody|CEAM3 antibody|CEAM3_HUMAN antibody|CGM1 antibody|Nonspecific cross reacting antigen antibody|W264 antibody|W282 antibody|Anti-CEACAM3 antibody (ab196606)

SCBT cat No:

Name

Rabbit polyclonal CEACAM3 antibody

Catalogue No.

A2589

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CEACAM3

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 27kDa/Observed: Refer to Figures

Formulation

CEACAM3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CEACAM3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CEA antibody, CGM1 antibody, W264 antibody, W282 antibody, CD66D antibody

Database links

Human UniProt/Swiss-Prot:P40198

Protein names

CEA, CGM1, W264, W282, CD66D

Protein function

Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.

Protein tissue specificity

CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney.

Protein sequence and domain

The cytosolic domain is involved in S100A9 interaction.Belongs to the immunoglobulin superfamily. CEA family.; Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Protein post-translational modifications

Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected.

Protein cellular localization

Membrane; Single-pass type I membrane protein.

Background

This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described.

Note

AntibodyPlus can customize CEACAM3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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