Rabbit polyclonal CELF1 antibody (A5958)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CELF1 antibody (A5958)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:200 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CELF1 antibody.

Alternative names:

Check alternative names for the antibody

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CUGBP antibody, NAB50 antibody, NAPOR antibody, CUG-BP antibody, CUGBP1 antibody, hNab50 antibody, BRUNOL2 antibody, EDEN-BP antibody
50 kDa Nuclear polyadenylated RNA binding protein antibody|50 kDa nuclear polyadenylated RNA-binding protein antibody|Bruno like 2 antibody|bruno like protein 2 antibody|Bruno-like protein 2 antibody|BRUNOL 2 antibody|BRUNOL2 antibody|CELF 1 antibody|CELF-1 antibody|celf1 antibody|CELF1 CUGBP, Elav like family member 1 antibody|CELF1_HUMAN antibody|CUG BP and ETR 3 like factor 1 antibody|CUG BP antibody|CUG BP1 antibody|CUG RNA binding protein antibody|CUG triplet repeat RNA binding protein 1 antibody|CUG triplet repeat RNA-binding protein 1 antibody|CUG-BP antibody|CUG-BP- and ETR-3-like factor 1 antibody|CUG-BP1 antibody|CUGBP 1 antibody|CUGBP and ETR3 like factor 1 antibody|CUGBP antibody|CUGBP Elav like family member 1 antibody|CUGBP Elav-like family member 1 antibody|CUGBP1 antibody|Cytidine uridine guanosine binding protein 1 antibody|Deadenylation factor CUG BP antibody|Deadenylation factor CUG-BP antibody|Deadenylation factor CUGBP antibody|EDEN BP antibody|EDEN BP homolog antibody|EDEN-BP antibody|EDEN-BP homolog antibody|embryo deadenylation element binding protein antibody|embryo deadenylation element binding protein homolog antibody|Embryo deadenylation element-binding protein homolog antibody|hNab 50 antibody|hNab50 antibody|NAB 50 antibody|NAB50 antibody|NAPOR antibody|Nuclear polyadenylated RNA binding protein 50 kD antibody|Nuclear polyadenylated RNA binding protein antibody|RNA binding protein BRUNOL 2 antibody|RNA binding protein BRUNOL2 antibody|RNA-binding protein BRUNOL-2 antibody|Anti-CUG-BP1 antibody [3B1] (ab9549)

SCBT cat No: sc-56649|sc-20003|sc-166095|sc-166096|sc-166198|

Name

Rabbit polyclonal CELF1 antibody

Catalogue No.

A5958

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human CELF1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:200 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 52kDa/Observed: Refer to Figures

Formulation

CELF1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CELF1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CUGBP antibody, NAB50 antibody, NAPOR antibody, CUG-BP antibody, CUGBP1 antibody, hNab50 antibody, BRUNOL2 antibody, EDEN-BP antibody

Database links

Human UniProt/Swiss-Prot:Q92879

Protein names

CUGBP, NAB50, NAPOR, CUG-BP, CUGBP1, hNab50, BRUNOL2, EDEN-BP

Protein function

RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3′-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3′-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5′-region of CDKN1A and CEBPB mRNAs. Binds with the 5′-region of CEBPB mRNA in aging liver.

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

RRM1 and RRM2 domains preferentially target UGU(U/G)-rich mRNA elements.Belongs to the CELF/BRUNOL family.; Contains 3 RRM (RNA recognition motif) domains.

Protein post-translational modifications

Phosphorylated. Its phosphorylation status increases in senescent cells.

Protein cellular localization

Nucleus . Cytoplasm . Note: RNA-binding activity is detected in both nuclear and cytoplasmic compartments.

Background

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms.

Note

AntibodyPlus can customize CELF1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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