Rabbit Polyclonal CEP290 antibody (STJ92224)

$99.00$319.00

Reactivity: Human, Mouse
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal CEP290 antibody (STJ92224)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for CEP290 Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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CEP290 antibody, BBS14 antibody, KIAA0373 antibody, NPHP6 antibody,|3H11AG antibody|Bardet-Biedl syndrome 14 protein antibody|BBS14 antibody|Cancer/testis antigen 87 antibody|CE290_HUMAN antibody|Centrosomal protein 290kDa antibody|Centrosomal protein of 290 kDa antibody|Cep290 antibody|CT87 antibody|CTCL tumor antigen se2 2 antibody|FLJ13615 antibody|FLJ21979 antibody|JBTS5 antibody|JBTS6 antibody|KIAA0373 antibody|LCA10 antibody|Meckel syndrome, type 4 antibody|MKS4 antibody|Monoclonal antibody 3H11 antigen antibody|Nephrocystin 6 antibody|Nephrocystin-6 antibody|NPHP6 antibody|POC3 antibody|POC3 centriolar protein homolog antibody|Prostate cancer antigen T21 antibody|rd16 antibody|SLSN6 1, 2, 5 antibody|SLSN6 antibody|Tumor antigen se2-2 antibody|Anti-CEP290 antibody (ab85728)
SCBT cat No: sc-390462|sc-390637|sc-292138|

 

Name

CEP290 Polyclonal Antibody

Catalogue No.

STJ92224

Reactivity

Human, Mouse

Specificity

CEP290 Polyclonal Antibody detects endogenous levels of CEP290 protein.

Immunogen

Synthesized peptide derived from CEP290 at AA range 740-820

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

290 kDa

Formulation

CEP290 Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

CEP290 Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Centrosomal protein of 290 kDa antibody, Cep290 antibody, Bardet-Biedl syndrome 14 protein antibody, Cancer/testis antigen 87 antibody, CT87 antibody, Nephrocystin-6 antibody, Tumor antigen se2-2 antibody

Database links

Human UniProt/Swiss-Prot:O15078;Mouse UniPort/Swiss-Prot: Q6A078;Rat UniProt/Swiss-Port: A0A0G2K715;Human Entrez Gene: 80184;Mouse Entrez Gene: 216274;Rat Entrez Gene: Rn.162935

Protein names

Centrosomal protein of 290 kDa , Cep290 , Bardet-Biedl syndrome 14 protein , Cancer/testis antigen 87 , CT87 , Nephrocystin-6 , Tumor antigen se2-2

Protein function

Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Activates ATF4-mediated transcription. Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes.

Protein tissue specificity

Ubiquitous. Expressed strongly in placenta and weakly in brain.

Involvement in disease

Joubert syndrome 5 (JBTS5) [MIM:610188]: A disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease. Joubert syndrome type 5 shares the neurologic and neuroradiologic features of Joubert syndrome together with severe retinal dystrophy and/or progressive renal failure characterized by nephronophthisis. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Senior-Loken syndrome 6 (SLSN6) [MIM:610189]: A renal-retinal disorder characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease. Typically this disorder becomes apparent during the first year of life. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Leber congenital amaurosis 10 (LCA10) [MIM:611755]: A severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Meckel syndrome 4 (MKS4) [MIM:611134]: A disorder characterized by a combination of renal cysts and variably associated features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia and cysts, and polydactyly. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Note: Antibodies against CEP290 are present in sera from patients with cutaneous T-cell lymphomas, but not in the healthy control population. .; Bardet-Biedl syndrome 14 (BBS14) [MIM:615991]: A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein post-translational modifications

Ubiquitinated. May undergo monoubiquitination; monoubiquitination is inhibited in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, but does not cause it displacement from centriolar satellites.

Protein cellular localization

Cytoplasm > cytoskeleton > microtubule organizing center > centrosome / Cytoplasm > cytoskeleton > microtubule organizing center > centrosome > centriolar satellite / Nucleus / Cell projection > cilium / Cytoplasm > cytoskeleton > cilium basal body / Cytoplasm > cytoskeleton > microtubule organizing center > centrosome > centriole

Research area

All research areas>Signaling Intermediates>CEP290
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize CEP290 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

Reviews


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Antibody customer reviews & validation data - 16

Validation data ID: 16

Submission date: 2016-11-23

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Result figure:
Result figure

Figure description:

Green signal is the stained basal bodies of olfactory sensory neurons in the developing mouse olfactory epithelium (P14)

Result figure:
blank2.pdf

Figure description:

no western tested

Product name

Rabbit anti-CEP290

Product catalog No.

STJ92224

Product type

Primary antibody

Supplier

St John's Laboratory Ltd

Application type

Immunofluorescence (IF)

Antibody specificity rating

Good

Antibody overall rating

Good

Your comments

this antibody stained basal bodies in the developing mouse olfactory epithelium as expected

Detailed protocol

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