Rabbit polyclonal CFB antibody (A1706)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CFB antibody (A1706)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

BF antibody, FB antibody, BFD antibody, GBG antibody, CFAB antibody, PBF2 antibody, AHUS4 antibody, FBI12 antibody, H2-Bf antibody
C3/C5 convertase antibody|Complement factor B antibody|Glycine-rich beta glycoprotein antibody|PBF2 antibody|Properdin factor B antibody|Anti-Complement factor B antibody [M13/12] (ab106139)

SCBT cat No: sc-69772|sc-57506|sc-47681|sc-271636|sc-67141|sc-47682|sc-47680|sc-34888|sc-47679|

Name

Rabbit polyclonal CFB antibody

Catalogue No.

A1706

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CFB

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 86kDa/Observed: Refer to Figures

Formulation

CFB antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CFB antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

BF antibody, FB antibody, BFD antibody, GBG antibody, CFAB antibody, PBF2 antibody, AHUS4 antibody, FBI12 antibody, H2-Bf antibody

Database links

Human UniProt/Swiss-Prot:P00751

Protein names

BF, FB, BFD, GBG, CFAB, PBF2, AHUS4, FBI12, H2-Bf

Protein function

Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.

Protein sequence and domain

The unliganded VWA domain has an inactive ‘locked’ conformation whereby the scissile Arg-259, Lys-260 bond is protected from proteolytic activation.Belongs to the peptidase S1 family.; Contains 1 peptidase S1 domain.; Contains 3 Sushi (CCP/SCR) domains.; Contains 1 VWFA domain.

Protein cellular localization

Secreted.

Background

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5′ end of the gene for complement component 2.

Research area

All research areas>Signaling Intermediates>Coagulation Factor
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize CFB antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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