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Rabbit polyclonal CFL2 antibody (A8009)
Supplier: ABclonal Inc.
Recommended applications: WB,IF
WB 1:500 – 1:2000 IF 1:50 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal CFL2 antibody.
Check alternative names for the antibodyExpand
CFL 2 antibody|CFL2 antibody|COF2_HUMAN antibody|Cofilin 2 muscle antibody|Cofilin antibody|Cofilin muscle antibody|Cofilin muscle isoform antibody|Cofilin-2 antibody|Cofilin2 antibody|muscle isoform antibody|NEM 7 antibody|NEM7 antibody|Anti-Cofilin 2 antibody – C-terminal (ab179935)
SCBT cat No: sc-166958|sc-32160|
Rabbit polyclonal CFL2 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human CFL2
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 19kDa/Observed: Refer to figures
CFL2 antibody was tube-contained.
CFL2 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 . It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity).
|Protein tissue specificity|| |
Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues.
|Protein sequence and domain|| |
Belongs to the actin-binding proteins ADF family.; Contains 1 ADF-H domain.
|Protein post-translational modifications|| |
The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.
|Protein cellular localization|| |
Nucleus matrix . Cytoplasm, cytoskeleton . Note: Colocalizes with CSPR3 in the Z line of sarcomeres.
This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.
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|Product type|| |
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