Rabbit polyclonal CFL2 antibody (A8009)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CFL2 antibody (A8009)

Supplier: ABclonal Inc.

Recommended applications: WB,IF

Recommended dilution:

WB 1:500 – 1:2000 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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NEM7 antibody
CFL 2 antibody|CFL2 antibody|COF2_HUMAN antibody|Cofilin 2 muscle antibody|Cofilin antibody|Cofilin muscle antibody|Cofilin muscle isoform antibody|Cofilin-2 antibody|Cofilin2 antibody|muscle isoform antibody|NEM 7 antibody|NEM7 antibody|Anti-Cofilin 2 antibody – C-terminal (ab179935)

SCBT cat No: sc-166958|sc-32160|

Name

Rabbit polyclonal CFL2 antibody

Catalogue No.

A8009

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CFL2

Host

Rabbit

Applications

WB, IF

Recommended dilution

WB 1:500 – 1:2000
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 19kDa/Observed: Refer to figures

Formulation

CFL2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CFL2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NEM7 antibody

Database links

Human UniProt/Swiss-Prot:Q9Y281

Protein names

NEM7

Protein function

Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 . It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity).

Protein tissue specificity

Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues.

Protein sequence and domain

Belongs to the actin-binding proteins ADF family.; Contains 1 ADF-H domain.

Protein post-translational modifications

The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.

Protein cellular localization

Nucleus matrix . Cytoplasm, cytoskeleton . Note: Colocalizes with CSPR3 in the Z line of sarcomeres.

Background

This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.

Research area

All research areas>Structural Proteins>Cofilin
(View all antibody categories related to Structural Proteins)

Note

AntibodyPlus can customize CFL2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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