Rabbit polyclonal CHM antibody (A8345)

$69.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CHM antibody (A8345)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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TCD antibody, GGTA antibody, REP-1 antibody, DXS540 antibody, HSD-32 antibody
CHM antibody|Chm antibody|Choroideraemia protein antibody|Choroideremia antibody|DXS540 antibody|FLJ38564 antibody|GGTA antibody|HSD 32 antibody|MGC102710 antibody|Rab escort protein 1 antibody|Rab geranylgeranyltransferase component A antibody|Rab proteins geranylgeranyltransferase component A 1 antibody|RAE1_HUMAN antibody|REP 1 antibody|REP-1 antibody|REP1 antibody|TCD antibody|TCD protein antibody|Anti-CHM antibody [EPR7142] (ab134964)

SCBT cat No: sc-23905|sc-14759|

Name

Rabbit polyclonal CHM antibody

Catalogue No.

A8345

Reactivity

Human

Immunogen

Recombinant protein of human CHM

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 73kDa/Observed: Refer to figures

Formulation

CHM antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CHM antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

TCD antibody, GGTA antibody, REP-1 antibody, DXS540 antibody, HSD-32 antibody

Database links

Human UniProt/Swiss-Prot:P24386

Protein names

TCD, GGTA, REP-1, DXS540, HSD-32

Protein function

Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation.

Protein sequence and domain

Belongs to the Rab GDI family.

Protein cellular localization

Cytoplasm, cytosol .

Background

This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternative splicing results in multiple transcript variants encoding different isoforms.

Research area

All research areas>GDP/GTP Binding Proteins>REP
(View all antibody categories related to GDP/GTP Binding Proteins)

Note

AntibodyPlus can customize CHM antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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