Rabbit Polyclonal CHMP2A antibody (A10380)

$99.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal CHMP2A antibody (A10380)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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BC2 antibody; BC-2 antibody; VPS2 antibody; CHMP2 antibody; VPS2A antibody;
BC2 antibody|Charged multivesicular body protein 2a antibody|CHM2A_HUMAN antibody|CHMP2 antibody|CHMP2a antibody|Chromatin modifying protein 2a antibody|Chromatin-modifying protein 2a antibody|hVps2 1 antibody|hVps2-1 antibody|putative breast adenocarcinoma marker antibody|Putative breast adenocarcinoma marker BC-2 antibody|Putative breast adenocarcinoma marker BC2 antibody|Vacuolar protein sorting associated protein 2 1 antibody|Vacuolar protein sorting-associated protein 2-1 antibody|Vps2 1 antibody|VPS2 antibody|Vps2-1 antibody|VPS2A antibody|Anti-CHMP2A antibody (ab67064)

SCBT cat No: sc-49905|sc-67227|

Name

Rabbit Polyclonal CHMP2A antibody

Catalogue No.

A10380

Reactivity

Human

Immunogen

Recombinant protein of human CHMP2A

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

24kDa

Formulation

CHMP2A antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

BC2 antibody; BC-2 antibody; VPS2 antibody; CHMP2 antibody; VPS2A antibody;

Protein names

BC2; BC-2; VPS2; CHMP2; VPS2A;

Protein function

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.; (Microbial infection) The ESCRT machinery functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Involved in HIV-1 p6- and p9-dependent virus release.

Protein sequence and domain

Belongs to the SNF7 family. The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components.

Protein post-translational modifications

ISGylated in a CHMP5-dependent manner. Isgylation weakens and inhibits its interactions with VPS4A and VTA1 respectively.

Protein cellular localization

Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.

Background

CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006

Note

AntibodyPlus can customize CHMP2A antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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