Rabbit polyclonal CHMP2B antibody (A5399)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CHMP2B antibody (A5399)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

DMT1 antibody, ALS17 antibody, VPS2B antibody, VPS2-2 antibody, CHMP2.5 antibody
ALS17 antibody|Charged multivesicular body protein 2b antibody|CHM2B_HUMAN antibody|CHMP family, member 2B antibody|CHMP2.5 antibody|CHMP2b antibody|Chromatin modifying protein 2b antibody|Chromatin-modifying protein 2b antibody|DMT1 antibody|hVps2-2 antibody|Vacuolar protein sorting 2, yeast, homolog of, B antibody|Vacuolar protein sorting 2-2 antibody|Vacuolar protein sorting-associated protein 2-2 antibody|VPS2 homolog B antibody|Vps2-2 antibody|VPS2B antibody|Anti-CHMP2B antibody (ab33174)

SCBT cat No: sc-69351|sc-98550|sc-69352|

Name

Rabbit polyclonal CHMP2B antibody

Catalogue No.

A5399

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CHMP2B

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 24kDa/Observed: Refer to Figures

Formulation

CHMP2B antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CHMP2B antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

DMT1 antibody, ALS17 antibody, VPS2B antibody, VPS2-2 antibody, CHMP2.5 antibody

Database links

Human UniProt/Swiss-Prot:Q9UQN3

Protein names

DMT1, ALS17, VPS2B, VPS2-2, CHMP2.5

Protein function

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.

Protein tissue specificity

Widely expressed. Expressed in brain, heart, skeletal muscle, spleen, kidney, liver, small intestine, pancreas, lung, placenta and leukocytes. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal chord, occipital lobe, frontal lobe, temporal lobe and putamen.

Protein sequence and domain

The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components (By similarity).Belongs to the SNF7 family.

Protein cellular localization

Cytoplasm, cytosol . Late endosome membrane ; Peripheral membrane protein .

Background

This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration.

Note

AntibodyPlus can customize CHMP2B antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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