Rabbit polyclonal CHRNA7 antibody (A1588)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CHRNA7 antibody (A1588)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CHRNA7 antibody.

Alternative names:

Check alternative names for the antibody

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NACHRA7 antibody, CHRNA7-2 antibody
7nAChR antibody|a7 nicotinic acetylcholine receptor antibody|acetylcholine receptor, neuronal nicotinic, alpha-7 subunit antibody|ACHA7_HUMAN antibody|AChR antibody|Acra7 antibody|alpha 7 neuronal nicotinic acetylcholine receptor antibody|alpha-7 nicotinic cholinergic receptor subunit antibody|alpha7 antibody|cholinergic receptor, neuronal nicotinic, alpha polypeptide 7 antibody|cholinergic receptor, nicotinic, alpha 7 (neuronal) antibody|cholinergic receptor, nicotinic, alpha 7 antibody|cholinergic receptor, nicotinic, alpha polypeptide 7 antibody|CHRNA7 antibody|CHRNA7-2 antibody|NACHRA7 antibody|neuronal acetylcholine receptor protein, alpha-7 chain antibody|Neuronal acetylcholine receptor subunit alpha-7 antibody|Anti-Nicotinic Acetylcholine Receptor alpha 7 antibody (ab10096)

SCBT cat No: sc-58607|sc-1447|sc-5544|sc-293282|

Name

Rabbit polyclonal CHRNA7 antibody

Catalogue No.

A1588

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CHRNA7

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 56kDa/Observed: Refer to figures

Formulation

CHRNA7 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CHRNA7 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NACHRA7 antibody, CHRNA7-2 antibody

Database links

Human UniProt/Swiss-Prot:P36544

Protein names

NACHRA7, CHRNA7-2

Protein function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

Protein sequence and domain

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub-subfamily.

Protein cellular localization

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Background

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants.

Research area

All research areas>Channel Proteins>AChR
(View all antibody categories related to Channel Proteins)

Note

AntibodyPlus can customize CHRNA7 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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