Rabbit polyclonal CIRBP antibody (A6559)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CIRBP antibody (A6559)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100 IF 1:10 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CIRP antibody
A18 hnRNP antibody|A18HNRNP antibody|cirbp antibody|CIRBP_HUMAN antibody|CIRP antibody|Cold inducible RNA binding protein antibody|Cold-inducible RNA-binding protein antibody|Glycine rich RNA binding protein antibody|Glycine-rich RNA-binding protein CIRP antibody|testicular tissue protein Li 39 antibody|Anti-CIRBP antibody [EPR18783] (ab191885)

SCBT cat No: sc-293325|sc-161012|sc-133460|

Name

Rabbit polyclonal CIRBP antibody

Catalogue No.

A6559

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CIRBP

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 18kDa/Observed: Refer to figures

Formulation

CIRBP antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CIRBP antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CIRP antibody

Database links

Human UniProt/Swiss-Prot:Q14011

Protein names

CIRP

Protein function

Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3′-untranslated regions (3′-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

Both the RRM domain and the arginine, glycine (RGG) rich domain are necessary for binding to the TXN 3′-untranslated region. Both the RRM domain and the arginine, glycine (RGG) rich domain (RGG repeats) are necessary for optimal recruitment into SGs upon cellular stress. The C-terminal domain containing RGG repeats is necessary for translational repression (By similarity).Contains 1 RRM (RNA recognition motif) domain.

Protein post-translational modifications

Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs (By similarity).; Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3′-UTR transcript upon exposure to UV radiation.

Protein cellular localization

Nucleus, nucleoplasm . Cytoplasm . Note: Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity).

Note

AntibodyPlus can customize CIRBP antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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