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Rabbit polyclonal CIRBP antibody (A6559)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:100 IF 1:10 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal CIRBP antibody.
Check alternative names for the antibodyExpand
A18 hnRNP antibody|A18HNRNP antibody|cirbp antibody|CIRBP_HUMAN antibody|CIRP antibody|Cold inducible RNA binding protein antibody|Cold-inducible RNA-binding protein antibody|Glycine rich RNA binding protein antibody|Glycine-rich RNA-binding protein CIRP antibody|testicular tissue protein Li 39 antibody|Anti-CIRBP antibody [EPR18783] (ab191885)
SCBT cat No: sc-293325|sc-161012|sc-133460|
Rabbit polyclonal CIRBP antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human CIRBP
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 18kDa/Observed: Refer to figures
CIRBP antibody was tube-contained.
CIRBP antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3′-untranslated regions (3′-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.
|Protein tissue specificity|| |
|Protein sequence and domain|| |
Both the RRM domain and the arginine, glycine (RGG) rich domain are necessary for binding to the TXN 3′-untranslated region. Both the RRM domain and the arginine, glycine (RGG) rich domain (RGG repeats) are necessary for optimal recruitment into SGs upon cellular stress. The C-terminal domain containing RGG repeats is necessary for translational repression (By similarity).Contains 1 RRM (RNA recognition motif) domain.
|Protein post-translational modifications|| |
Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs (By similarity).; Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3′-UTR transcript upon exposure to UV radiation.
|Protein cellular localization|| |
Nucleus, nucleoplasm . Cytoplasm . Note: Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity).
AntibodyPlus can customize CIRBP antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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