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Rabbit polyclonal CLASP1 antibody (A7081)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
1700030C23Rik antibody|5730583A19Rik antibody|B130045P17Rik antibody|CLAP1_HUMAN antibody|clasp1 antibody|CLIP associating protein 1 antibody|CLIP associating protein CLASP1 antibody|CLIP-associating protein 1 antibody|Cytoplasmic linker associated protein 1 antibody|Cytoplasmic linker-associated protein 1 antibody|DKFZp686D1968 antibody|DKFZp686H2039 antibody|FLJ33821 antibody|FLJ41222 antibody|hOrbit1 antibody|KIAA0622 antibody|MAST1 antibody|MGC131895 antibody|mKIAA0622 antibody|Multiple asters 1 antibody|Multiple asters homolog 1 antibody|Protein Orbit homolog 1 antibody|Anti-CLASP1 antibody [EPR3409] (ab108620)
SCBT cat No: sc-390159|sc-33474|
Rabbit polyclonal CLASP1 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human CLASP1
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 169kDa/Observed: Refer to figures
CLASP1 antibody was tube-contained.
CLASP1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
|Protein sequence and domain|| |
Belongs to the CLASP family.; Contains 7 HEAT repeats.
|Protein cellular localization|| |
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus, trans-Golgi network . Note: Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2.
CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003
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|Product type|| |
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