Rabbit polyclonal CLASP1 antibody (A7081)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CLASP1 antibody (A7081)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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MAST1 antibody
1700030C23Rik antibody|5730583A19Rik antibody|B130045P17Rik antibody|CLAP1_HUMAN antibody|clasp1 antibody|CLIP associating protein 1 antibody|CLIP associating protein CLASP1 antibody|CLIP-associating protein 1 antibody|Cytoplasmic linker associated protein 1 antibody|Cytoplasmic linker-associated protein 1 antibody|DKFZp686D1968 antibody|DKFZp686H2039 antibody|FLJ33821 antibody|FLJ41222 antibody|hOrbit1 antibody|KIAA0622 antibody|MAST1 antibody|MGC131895 antibody|mKIAA0622 antibody|Multiple asters 1 antibody|Multiple asters homolog 1 antibody|Protein Orbit homolog 1 antibody|Anti-CLASP1 antibody [EPR3409] (ab108620)

SCBT cat No: sc-390159|sc-33474|

Name

Rabbit polyclonal CLASP1 antibody

Catalogue No.

A7081

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CLASP1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 169kDa/Observed: Refer to figures

Formulation

CLASP1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CLASP1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MAST1 antibody

Database links

Human UniProt/Swiss-Prot:Q7Z460

Protein names

MAST1

Protein function

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.

Protein sequence and domain

Belongs to the CLASP family.; Contains 7 HEAT repeats.

Protein cellular localization

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus, trans-Golgi network . Note: Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2.

Background

CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003

Note

AntibodyPlus can customize CLASP1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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