Rabbit polyclonal CLDN1 antibody (A2196)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CLDN1 antibody (A2196)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CLD1 antibody, ILVASC antibody, SEMP1 antibody
Claudin-1 antibody|Claudin1 antibody|CLD 1 antibody|CLD1 antibody|CLD1_HUMAN antibody|CLDN 1 antibody|Cldn1 antibody|ILVASC antibody|SEMP 1 antibody|SEMP1 antibody|Senescence associated epithelial membrane protein 1 antibody|Senescence associated epithelial membrane protein antibody|Senescence-associated epithelial membrane protein antibody|Anti-Claudin 1 antibody (ab15098)

SCBT cat No: sc-22932|sc-166338|sc-17658|sc-137121|sc-81796|sc-28668|

Name

Rabbit polyclonal CLDN1 antibody

Catalogue No.

A2196

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CLDN1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 23kDa/Observed: Refer to Figures

Formulation

CLDN1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CLDN1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CLD1 antibody, ILVASC antibody, SEMP1 antibody

Database links

Human UniProt/Swiss-Prot:O95832

Protein names

CLD1, ILVASC, SEMP1

Protein function

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions .; (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes . Acts as a receptor for dengue virus .

Protein tissue specificity

Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.

Protein sequence and domain

Belongs to the claudin family.

Protein cellular localization

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Background

Tight junctions, or zonula occludens, form a continuous barrier to fluids across the epithelium and endothelium. They function in regulation of paracellular permeability and in the maintenance of cell polarity, blocking the movement of transmembrane proteins between the apical and the basolateral cell surfaces. Tight junctions are composed of claudin and occludin proteins, which join the junctions to the cytoskeleton (1,2). The claudin family is composed of 23 integral membrane proteins, and their expression, which varies among tissue types, may determine both the strength and properties of the epithelial barrier. Alteration in claudin protein expression pattern is associated with several types of cancer (2,3). Claudin-1 is expressed primarily in keratinocytes (4) and normal mammary epithelial cells, but is absent or reduced in breast carcinomas and breast cancer cell lines (5,6).

Research area

All research areas>Cell Adhesion Proteins>Claudin
(View all antibody categories related to Cell Adhesion Proteins)

Note

AntibodyPlus can customize CLDN1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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