Rabbit polyclonal CLDN7 antibody (A2035)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CLDN7 antibody (A2035)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CLDN-7 antibody, CEPTRL2 antibody, CPETRL2 antibody, Hs.84359 antibody, claudin-1 antibody
CEPTR L2 antibody|CEPTRL 2 antibody|CEPTRL2 antibody|Claudin 1 antibody|Claudin 9 antibody|Claudin-7 antibody|Claudin1 antibody|Claudin7 antibody|Claudin9 antibody|CLD7_HUMAN antibody|CLDN 7 antibody|CLDN-7 antibody|CLDN7 antibody|Clostridium perfringens enterotoxin receptor like 2 antibody|CPETR L2 antibody|CPETRL 2 antibody|CPETRL2 antibody|Hs.84359 antibody|Anti-Claudin 7 antibody (ab27487)

SCBT cat No: sc-17670|sc-33532|

Name

Rabbit polyclonal CLDN7 antibody

Catalogue No.

A2035

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CLDN7

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 24kDa/Observed: Refer to Figures

Formulation

CLDN7 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CLDN7 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CLDN-7 antibody, CEPTRL2 antibody, CPETRL2 antibody, Hs.84359 antibody, claudin-1 antibody

Database links

Human UniProt/Swiss-Prot:O95471

Protein names

CLDN-7, CEPTRL2, CPETRL2, Hs.84359, claudin-1

Protein function

Plays a major role in tight junction-specific obliteration of the intercellular space.

Protein tissue specificity

Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.

Protein sequence and domain

Belongs to the claudin family.

Protein post-translational modifications

Phosphorylated.

Protein cellular localization

Cell membrane; Multi-pass membrane protein. Lateral cell membrane. Cell junction, tight junction. Note: Co-localizes with EPCAM at the lateral cell membrane and tight junction.

Background

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010].

Research area

All research areas>Cell Adhesion Proteins>Claudin
(View all antibody categories related to Cell Adhesion Proteins)

Note

AntibodyPlus can customize CLDN7 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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