Rabbit Polyclonal Cleaved-Aggrecan (D369) antibody (STJ90041)


Reactivity: Human, Rat
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Cleaved-Aggrecan (D369) antibody (STJ90041)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody


ACAN antibody, AGC1 antibody, CSPG1 antibody, MSK16 antibody,|ACAN antibody|AGC 1 antibody|AGC1 antibody|AGCAN antibody|Aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122) antibody|Aggrecan 1 antibody|Aggrecan core protein antibody|Aggrecan proteoglycan antibody|Aggrecan structural proteoglycan of cartilage antibody|Aggrecan1 antibody|ATEGQV antibody|Cartilage specific proteoglycan core protein antibody|Chondroitin sulfate proteoglycan 1 antibody|Chondroitin sulfate proteoglycan 1 large aggregating proteoglycan antigen identified by monoclonal antibody A0122 antibody|Chondroitin sulfate proteoglycan core protein 1 antibody|CSPG 1 antibody|CSPG1 antibody|CSPGCP antibody|JSCATE antibody|Large aggregating proteoglycan antibody|mcspg antibody|mgsk16 antibody|MSK 16 antibody|MSK16 antibody|SEDK antibody|Anti-Aggrecan antibody (ab36861)
SCBT cat No: sc-70333|sc-70332|sc-33695|sc-70334|sc-16492|sc-67513|sc-25674|sc-81542|sc-16493|sc-166951|



Cleaved-Aggrecan (D369) Polyclonal Antibody

Catalogue No.



Human, Rat


Cleaved-Aggrecan (D369) Polyclonal Antibody detects endogenous levels of fragment of activated Aggrecan protein resulting from cleavage adjacent to D369.


Synthesized peptide derived from Cleaved-Aggrecan (D369) at AA range 290-370





Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;







Molecular weight

44/72 kDa


Cleaved-Aggrecan (D369) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.


1 mg/ml


Cleaved-Aggrecan (D369) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.


-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Aggrecan core protein antibody, Cartilage-specific proteoglycan core protein antibody, CSPCP antibody, Chondroitin sulfate proteoglycan core protein 1 antibody, Chondroitin sulfate proteoglycan 1 antibody

Database links

Human UniProt/Swiss-Prot:P16112;Mouse UniPort/Swiss-Prot: Q61282;Rat UniProt/Swiss-Port: P07897;Human Entrez Gene: 176;Mouse Entrez Gene: 11595;Rat Entrez Gene: Rn.54503

Protein names

Aggrecan core protein , Cartilage-specific proteoglycan core protein , CSPCP , Chondroitin sulfate proteoglycan core protein 1 , Chondroitin sulfate proteoglycan 1

Protein function

This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.

Protein tissue specificity

Restricted to cartilages.

Involvement in disease

Spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]: Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Spondyloepimetaphyseal dysplasia aggrecan type (SEMD-ACAN) [MIM:612813]: A bone disease characterized by severe short stature, macrocephaly, severe midface hypoplasia, short neck, barrel chest and brachydactyly. The radiological findings comprise long bones with generalized irregular epiphyses with widened metaphyses, especially at the knees, platyspondyly, and multiple cervical-vertebral clefts. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Osteochondritis dissecans short stature and early-onset osteoarthritis (OD) [MIM:165800]: A type of osteochondritis defined as a separation of cartilage and subchondral bone from the surrounding tissue, primarily affecting the knee, ankle and elbow joints. It is clinically characterized by multiple osteochondritic lesions in knees and/or hips and/or elbows, disproportionate short stature and early-onset osteoarthritis. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B’ motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3. / Belongs to the aggrecan/versican proteoglycan family. / Contains 1 C-type lectin domain. / Contains 1 EGF-like domain. / Contains 1 Ig-like V-type (immunoglobulin-like) domain. / Contains 4 Link domains. / Contains 1 Sushi (CCP/SCR) domain.

Protein post-translational modifications

Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.

Protein cellular localization

Secreted > extracellular space > extracellular matrix


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St John’s Laboratory Ltd.

Product type

Primary antibody


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