Rabbit Polyclonal Cleaved-Aggrecan (D369) antibody (STJ90041)

$99.00$319.00

Reactivity: Human, Rat
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Polyclonal Cleaved-Aggrecan (D369) antibody (STJ90041)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Cleaved-Aggrecan (D369) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

Expand

ACAN antibody, AGC1 antibody, CSPG1 antibody, MSK16 antibody,|ACAN antibody|AGC 1 antibody|AGC1 antibody|AGCAN antibody|Aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122) antibody|Aggrecan 1 antibody|Aggrecan core protein antibody|Aggrecan proteoglycan antibody|Aggrecan structural proteoglycan of cartilage antibody|Aggrecan1 antibody|ATEGQV antibody|Cartilage specific proteoglycan core protein antibody|Chondroitin sulfate proteoglycan 1 antibody|Chondroitin sulfate proteoglycan 1 large aggregating proteoglycan antigen identified by monoclonal antibody A0122 antibody|Chondroitin sulfate proteoglycan core protein 1 antibody|CSPG 1 antibody|CSPG1 antibody|CSPGCP antibody|JSCATE antibody|Large aggregating proteoglycan antibody|mcspg antibody|mgsk16 antibody|MSK 16 antibody|MSK16 antibody|SEDK antibody|Anti-Aggrecan antibody (ab36861)
SCBT cat No: sc-70333|sc-70332|sc-33695|sc-70334|sc-16492|sc-67513|sc-25674|sc-81542|sc-16493|sc-166951|

 

Name

Cleaved-Aggrecan (D369) Polyclonal Antibody

Catalogue No.

STJ90041

Reactivity

Human, Rat

Specificity

Cleaved-Aggrecan (D369) Polyclonal Antibody detects endogenous levels of fragment of activated Aggrecan protein resulting from cleavage adjacent to D369.

Immunogen

Synthesized peptide derived from Cleaved-Aggrecan (D369) at AA range 290-370

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

44/72 kDa

Formulation

Cleaved-Aggrecan (D369) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Cleaved-Aggrecan (D369) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Aggrecan core protein antibody, Cartilage-specific proteoglycan core protein antibody, CSPCP antibody, Chondroitin sulfate proteoglycan core protein 1 antibody, Chondroitin sulfate proteoglycan 1 antibody

Database links

Human UniProt/Swiss-Prot:P16112;Mouse UniPort/Swiss-Prot: Q61282;Rat UniProt/Swiss-Port: P07897;Human Entrez Gene: 176;Mouse Entrez Gene: 11595;Rat Entrez Gene: Rn.54503

Protein names

Aggrecan core protein , Cartilage-specific proteoglycan core protein , CSPCP , Chondroitin sulfate proteoglycan core protein 1 , Chondroitin sulfate proteoglycan 1

Protein function

This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.

Protein tissue specificity

Restricted to cartilages.

Involvement in disease

Spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]: Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Spondyloepimetaphyseal dysplasia aggrecan type (SEMD-ACAN) [MIM:612813]: A bone disease characterized by severe short stature, macrocephaly, severe midface hypoplasia, short neck, barrel chest and brachydactyly. The radiological findings comprise long bones with generalized irregular epiphyses with widened metaphyses, especially at the knees, platyspondyly, and multiple cervical-vertebral clefts. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Osteochondritis dissecans short stature and early-onset osteoarthritis (OD) [MIM:165800]: A type of osteochondritis defined as a separation of cartilage and subchondral bone from the surrounding tissue, primarily affecting the knee, ankle and elbow joints. It is clinically characterized by multiple osteochondritic lesions in knees and/or hips and/or elbows, disproportionate short stature and early-onset osteoarthritis. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B’ motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3. / Belongs to the aggrecan/versican proteoglycan family. / Contains 1 C-type lectin domain. / Contains 1 EGF-like domain. / Contains 1 Ig-like V-type (immunoglobulin-like) domain. / Contains 4 Link domains. / Contains 1 Sushi (CCP/SCR) domain.

Protein post-translational modifications

Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.

Protein cellular localization

Secreted > extracellular space > extracellular matrix

Note

AntibodyPlus can customize Cleaved-Aggrecan (D369) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!