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Rabbit Polyclonal Cleaved-C1s HC (R437) antibody (STJ90019)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for Cleaved-C1s HC (R437) Polyclonal Antibody.
Check alternative names for the antibodyExpand
C1S antibody,|Basic proline rich peptide IB 1 antibody|C1 esterase antibody|C1S antibody|C1S_HUMAN antibody|Complement C1s subcomponent antibody|Complement C1s subcomponent heavy chain antibody|Complement C1s subcomponent light chain antibody|Complement component 1 s subcomponent antibody|Complement component 1 subcomponent s antibody|FLJ44757 antibody|Anti-C1s antibody [M81] (ab81707)
SCBT cat No: sc-365273|
Cleaved-C1s HC (R437) Polyclonal Antibody
|Catalogue No.|| |
Cleaved-C1s HC (R437) Polyclonal Antibody detects endogenous levels of fragment of activated C1s HC protein resulting from cleavage adjacent to R437.
Synthesized peptide derived from Cleaved-C1s HC (R437) at AA range 360-440
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:20000;
|Molecular weight|| |
Cleaved-C1s HC (R437) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cleaved-C1s HC (R437) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Complement C1s subcomponent antibody, C1 esterase antibody, Complement component 1 subcomponent s antibody
|Protein names|| |
Complement C1s subcomponent , C1 esterase , Complement component 1 subcomponent s
|Protein function|| |
C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. / Cleavage of Arg-, -Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-, -Lys bond in complement component C2 to form C2a and C2b: the ‘classical’ pathway C3 convertase. / Inhibited by SERPING1. / Less efficient than MASP2 in C4 cleavage. / 12.3 µM for complement component C2 (at 37 degrees Celsius) / 1.9 µM for complement component C4 (at 37 degrees Celsius)
|Involvement in disease|| |
Complement component C1s deficiency (C1SD) [MIM:613783]: A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the peptidase S1 family. / Contains 2 CUB domains. / Contains 1 EGF-like domain. / Contains 1 peptidase S1 domain. / Contains 2 Sushi (CCP/SCR) domains.
|Protein post-translational modifications|| |
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
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St John’s Laboratory Ltd.
|Product type|| |
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