Rabbit Polyclonal Cleaved-C1s HC (R437) antibody (STJ90019)

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Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Cleaved-C1s HC (R437) antibody (STJ90019)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Cleaved-C1s HC (R437) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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C1S antibody,|Basic proline rich peptide IB 1 antibody|C1 esterase antibody|C1S antibody|C1S_HUMAN antibody|Complement C1s subcomponent antibody|Complement C1s subcomponent heavy chain antibody|Complement C1s subcomponent light chain antibody|Complement component 1 s subcomponent antibody|Complement component 1 subcomponent s antibody|FLJ44757 antibody|Anti-C1s antibody [M81] (ab81707)
SCBT cat No: sc-365273|

 

Name

Cleaved-C1s HC (R437) Polyclonal Antibody

Catalogue No.

STJ90019

Reactivity

Human

Specificity

Cleaved-C1s HC (R437) Polyclonal Antibody detects endogenous levels of fragment of activated C1s HC protein resulting from cleavage adjacent to R437.

Immunogen

Synthesized peptide derived from Cleaved-C1s HC (R437) at AA range 360-440

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

47/76 kDa

Formulation

Cleaved-C1s HC (R437) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Cleaved-C1s HC (R437) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Complement C1s subcomponent antibody, C1 esterase antibody, Complement component 1 subcomponent s antibody

Database links

Human UniProt/Swiss-Prot:P09871;Mouse UniPort/Swiss-Prot: Q8CG14;Rat UniProt/Swiss-Port: Q6P6T1;Human Entrez Gene: 716;Mouse Entrez Gene: 50908;Rat Entrez Gene: Rn.4037

Protein names

Complement C1s subcomponent , C1 esterase , Complement component 1 subcomponent s

Protein function

C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. / Cleavage of Arg-, -Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-, -Lys bond in complement component C2 to form C2a and C2b: the ‘classical’ pathway C3 convertase. / Inhibited by SERPING1. / Less efficient than MASP2 in C4 cleavage. / 12.3 µM for complement component C2 (at 37 degrees Celsius) / 1.9 µM for complement component C4 (at 37 degrees Celsius)

Involvement in disease

Complement component C1s deficiency (C1SD) [MIM:613783]: A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the peptidase S1 family. / Contains 2 CUB domains. / Contains 1 EGF-like domain. / Contains 1 peptidase S1 domain. / Contains 2 Sushi (CCP/SCR) domains.

Protein post-translational modifications

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

Research area

All research areas>Lymphocyte Signaling>C1s
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize Cleaved-C1s HC (R437) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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