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Rabbit Polyclonal Cleaved-Caspase-3 p17 (D175) antibody (STJ90004)
Supplier: St John’s Laboratory Ltd.
Recommended applications: IHC, ELISA
Recommended dilution: IHC 1:100-1:300; ELISA 1:20000;
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
CASP3 antibody, CPP32 antibody,|A830040C14Rik antibody|Caspase-3 subunit p12 antibody|CC3 antibody|CPP-32 antibody|CPP32 antibody|CPP32B antibody|Cysteine protease CPP32 antibody|EC 184.108.40.206 antibody|LICE antibody|mldy antibody|OTTHUMP00000165052 antibody|OTTHUMP00000165053 antibody|OTTHUMP00000165054 antibody|PARP cleavage protease antibody|Procaspase3 antibody|Protein Yama antibody|SCA 1 antibody|SCA-1 antibody|SREBP cleavage activity 1 antibody|Yama antibody|Anti-Caspase-3 antibody (ab13847)
SCBT cat No: sc-56053|sc-70497|sc-65496|sc-56046|sc-70498|sc-65497|sc-136219|sc-56050|sc-56051|sc-56052|sc-7272|sc-7148|sc-1225|sc-271759|sc-1224|sc-271028|sc-373730|sc-166589|sc-98785|sc-22139|sc-22140|sc-1226|sc-56056|sc-1229|
Cleaved-Caspase-3 p17 (D175) Polyclonal Antibody
|Catalogue No.|| |
Cleaved-Caspase-3 p17 (D175) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-3 p17 protein resulting from cleavage adjacent to D175.
Synthesized peptide derived from Cleaved-Caspase-3 p17 (D175) at AA range 110-190
|Recommended dilution|| |
IHC 1:100-1:300; ELISA 1:20000;
|Molecular weight|| |
Cleaved-Caspase-3 p17 (D175) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cleaved-Caspase-3 p17 (D175) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Caspase-3 antibody, CASP-3 antibody, Apopain antibody, Cysteine protease CPP32 antibody, CPP-32 antibody, Protein Yama antibody, SREBP cleavage activity 1 antibody, SCA-1 antibody
|Protein names|| |
Caspase-3 , CASP-3 , Apopain , Cysteine protease CPP32 , CPP-32 , Protein Yama , SREBP cleavage activity 1 , SCA-1
|Protein function|| |
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ‘216-Asp-, -Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. / Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-, – with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position. / Inhibited by isatin sulfonamides.
|Protein tissue specificity|| |
Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
|Protein sequence and domain|| |
Belongs to the peptidase C14A family.
|Protein post-translational modifications|| |
Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa. / S-nitrosylated on its catalytic site cysteine in unstimulated human cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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