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Rabbit Polyclonal Cleaved-Caspase-7 (S199) antibody (STJ90009)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000;
Recommended protocols: check protocols
Click or hover above images to see image description for Cleaved-Caspase-7 (S199) Polyclonal Antibody.
Check alternative names for the antibodyExpand
CASP7 antibody, MCH3 antibody,|Apoptotic protease Mch-3 antibody|Caspase-7 subunit p11 antibody|Caspase7 antibody|CMH 1 antibody|CMH-1 antibody|CMH1 antibody|ICE LAP3 antibody|ICE-LAP3 antibody|ICE-like apoptotic protease 3 antibody|LICE2 antibody|MCH3 antibody|Anti-Caspase-7 antibody [E22] (ab32522)
SCBT cat No: sc-81654|sc-56063|sc-81655|sc-73424|sc-135858|sc-81660|sc-56066|sc-56067|sc-6138|sc-56068|sc-365034|sc-271747|sc-28295|sc-133248|sc-133247|sc-33773|sc-8510|
Cleaved-Caspase-7 (S199) Polyclonal Antibody
|Catalogue No.|| |
Cleaved-Caspase-7 (S199) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-7 protein resulting from cleavage adjacent to S199.
Synthesized peptide derived from Cleaved-Caspase-7 (S199) at AA range 150-230
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000;
|Molecular weight|| |
Cleaved-Caspase-7 (S199) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cleaved-Caspase-7 (S199) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Caspase-7 antibody, CASP-7 antibody, Apoptotic protease Mch-3 antibody, CMH-1 antibody, ICE-like apoptotic protease 3 antibody, ICE-LAP3 antibody
|Protein names|| |
Caspase-7 , CASP-7 , Apoptotic protease Mch-3 , CMH-1 , ICE-like apoptotic protease 3 , ICE-LAP3
|Protein function|| |
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ‘216-Asp-, -Gly-217’ bond. Overexpression promotes programmed cell death. / Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-, -. / Inhibited by isatin sulfonamides.
|Protein tissue specificity|| |
Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.
|Protein sequence and domain|| |
Belongs to the peptidase C14A family.
|Protein post-translational modifications|| |
Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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