Rabbit Polyclonal Cleaved-Cathepsin C HC (R394) antibody (STJ90034)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Cleaved-Cathepsin C HC (R394) antibody (STJ90034)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Cleaved-Cathepsin C HC (R394) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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CTSC antibody, CPPI antibody,|AI047818 antibody|CATC antibody|CATC_HUMAN antibody|Cathepsin C antibody|Cathepsin J antibody|CPPI antibody|CTSC antibody|Dipeptidyl peptidase 1 antibody|Dipeptidyl peptidase 1 light chain antibody|Dipeptidyl peptidase I antibody|Dipeptidyl peptidase I exclusion domain chain antibody|Dipeptidyl peptidase I heavy chain antibody|Dipeptidyl peptidase I light chain antibody|Dipeptidyl transferase antibody|DPP I antibody|DPP-I antibody|DPPI antibody|EC 3.4.14.1 antibody|HMS antibody|JP antibody|JPD antibody|MGC126959 antibody|PALS antibody|PDON1 antibody|PLS antibody|Anti-DPP1 antibody [EPR7749] – C-terminal (ab192019)
SCBT cat No: sc-74590|sc-13986|sc-5647|

 

Name

Cleaved-Cathepsin C HC (R394) Polyclonal Antibody

Catalogue No.

STJ90034

Reactivity

Human

Specificity

Cleaved-Cathepsin C HC (R394) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin C HC protein resulting from cleavage adjacent to R394.

Immunogen

Synthesized peptide derived from Cleaved-Cathepsin C HC (R394) at AA range 320-400

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

27 kDa

Formulation

Cleaved-Cathepsin C HC (R394) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Cleaved-Cathepsin C HC (R394) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Dipeptidyl peptidase 1 antibody, Cathepsin C antibody, Cathepsin J antibody, Dipeptidyl peptidase I antibody, DPP-I antibody, DPPI antibody, Dipeptidyl transferase antibody

Database links

Human UniProt/Swiss-Prot:P53634;Mouse UniPort/Swiss-Prot: P97821;Rat UniProt/Swiss-Port: P80067;Human Entrez Gene: 1075;Mouse Entrez Gene: 13032;Rat Entrez Gene: Rn.203177

Protein names

Dipeptidyl peptidase 1 , Cathepsin C , Cathepsin J , Dipeptidyl peptidase I , DPP-I , DPPI , Dipeptidyl transferase

Protein function

Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII. / Release of an N-terminal dipeptide, Xaa-Yaa-, -Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro. / chloride / Strongly inhibited by the cysteine peptidase inhibitors mersalyl acid, iodoacetic acid and cystatin. Inhibited by N-ethylmaleimide, Gly-Phe-diazomethane, TLCK, TPCK and, at low pH, by dithiodipyridine. Not inhibited by the serine peptidase inhibitor PMSF, the aminopeptidase inhibitor bestatin, or metal ion chelators. / High activity at pH 4.5-6.8.

Protein tissue specificity

Ubiquitous. Highly expressed in lung, kidney and placenta. Detected at intermediate levels in colon, small intestine, spleen and pancreas.

Involvement in disease

Papillon-Lefevre syndrome (PLS) [MIM:245000]: An autosomal recessive disorder characterized by palmoplantar keratosis and severe periodontitis affecting deciduous and permanent dentitions and resulting in premature tooth loss. The palmoplantar keratotic phenotype vary from mild psoriasiform scaly skin to overt hyperkeratosis. Keratosis also affects other sites such as elbows and knees. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Haim-Munk syndrome (HMS) [MIM:245010]: An autosomal recessive disorder characterized by palmoplantar keratosis, onychogryphosis and periodontitis. Additional features are pes planus, arachnodactyly, and acroosteolysis. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Periodontititis, aggressive, 1 (AP1) [MIM:170650]: A disease characterized by severe and protracted gingival infections, generalized or localized, leading to tooth loss. Amounts of microbial deposits are generally inconsistent with the severity of periodontal tissue destruction and the progression of attachment and bone loss may be self arresting. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the peptidase C1 family.

Protein post-translational modifications

N-glycosylated. While glycosylation at Asn-53, Asn-119 and Asn-276 is mediated by STT3A-containing complexes, glycosylation at Asn-29 is mediated STT3B-containing complexes. / In approximately 50% of the complexes the exclusion domain is cleaved at position 58 or 61. The two parts of the exclusion domain are held together by a disulfide bond.

Protein cellular localization

Lysosome

Research area

All research areas>Synthesis and Degradation>Cathepsin
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize Cleaved-Cathepsin C HC (R394) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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