Rabbit Polyclonal Cleaved-COL1A2 (G1102) antibody (STJ90048)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Polyclonal Cleaved-COL1A2 (G1102) antibody (STJ90048)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Cleaved-COL1A2 (G1102) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

Expand

COL1A2 antibody,|Alpha 1 type I collagen antibody|Alpha 2 type I collagen antibody|alpha 2 type I procollagen antibody|alpha 2(I) procollagen antibody|alpha 2(I)-collagen antibody|Alpha-1 type I collagen antibody|alpha1(I) procollagen antibody|CO1A1_HUMAN antibody|COL1A1 antibody|COL1A2 antibody|collagen alpha 1 chain type I antibody|Collagen alpha-1(I) chain antibody|collagen alpha-1(I) chain preproprotein antibody|Collagen I alpha 1 polypeptide antibody|Collagen I alpha 2 polypeptide antibody|collagen of skin, tendon and bone, alpha-1 chain antibody|collagen of skin, tendon and bone, alpha-2 chain antibody|Collagen type I alpha 1 antibody|Collagen type I alpha 2 antibody|EDSC antibody|OI1 antibody|OI2 antibody|OI3 antibody|OI4 antibody|pro-alpha-1 collagen type 1 antibody|type I proalpha 1 antibody|type I procollagen alpha 1 chain antibody|Type I procollagen antibody|Anti-Collagen I antibody (ab34710)
SCBT cat No: sc-30136|

 

Name

Cleaved-COL1A2 (G1102) Polyclonal Antibody

Catalogue No.

STJ90048

Reactivity

Human

Specificity

Cleaved-COL1A2 (G1102) Polyclonal Antibody detects endogenous levels of fragment of activated COL1A2 protein resulting from cleavage adjacent to G1102.

Immunogen

Synthesized peptide derived from Cleaved-COL1A2 (G1102) at AA range 1020-1100

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

92 kDa

Formulation

Cleaved-COL1A2 (G1102) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Cleaved-COL1A2 (G1102) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Collagen alpha-2antibody, I antibody, chain antibody, Alpha-2 type I collagen antibody

Database links

Human UniProt/Swiss-Prot:P08123;Mouse UniPort/Swiss-Prot: Q01149;Rat UniProt/Swiss-Port: P02466;Human Entrez Gene: 1278;Mouse Entrez Gene: 12843;Rat Entrez Gene: Rn.107239

Protein names

Collagen alpha-2, I , chain , Alpha-2 type I collagen

Protein function

Type I collagen is a member of group I collagen (fibrillar forming collagen).

Protein tissue specificity

Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.

Involvement in disease

Ehlers-Danlos syndrome 7B (EDS7B) [MIM:130060]: A connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. Marked by bilateral congenital hip dislocation, hyperlaxity of the joints, and recurrent partial dislocations. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Osteogenesis imperfecta 1 (OI1) [MIM:166200]: An autosomal dominant form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI1 is a non-deforming form with normal height or mild short stature, and no dentinogenesis imperfecta. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Osteogenesis imperfecta 2 (OI2) [MIM:166210]: An autosomal dominant form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI2 is characterized by bone fragility, with many perinatal fractures, severe bowing of long bones, undermineralization, and death in the perinatal period due to respiratory insufficiency. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Ehlers-Danlos syndrome, autosomal recessive, cardiac valvular form (EDSCV) [MIM:225320]: A connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. In addition to joint laxity, skin hyperextensibility and friability, and abnormal scar formation, patients have mitral valve prolapse and insufficiency, mitral regurgitation, and aortic insufficiency. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Osteogenesis imperfecta 3 (OI3) [MIM:259420]: An autosomal dominant form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI3 is characterized by progressively deforming bones, very short stature, a triangular face, severe scoliosis, grayish sclera and dentinogenesis imperfecta. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Osteogenesis imperfecta 4 (OI4) [MIM:166220]: An autosomal dominant form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI4 is characterized by moderately short stature, mild to moderate scoliosis, grayish or white sclera and dentinogenesis imperfecta. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Note: A chromosomal aberration involving COL1A2 may be a cause of lipoblastomas, which are benign tumors resulting from transformation of adipocytes, usually diagnosed in children. Translocation t(7;8)(p22;q13) with PLAG1.

Protein sequence and domain

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity). / Belongs to the fibrillar collagen family. / Contains 1 fibrillar collagen NC1 domain.

Protein post-translational modifications

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Protein cellular localization

Secreted > extracellular space > extracellular matrix

Research area

All research areas>Cell Adhesion Proteins>Collagen
(View all antibody categories related to Cell Adhesion Proteins)

Note

AntibodyPlus can customize Cleaved-COL1A2 (G1102) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!