Rabbit Polyclonal Cleaved-COL3A1 (G1221) antibody (STJ90049)

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Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Cleaved-COL3A1 (G1221) antibody (STJ90049)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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COL3A1 antibody,|Alpha 1 type III collagen antibody|Alpha1 (III) collagen antibody|CO3A1_HUMAN antibody|COL 3A1 antibody|COL3A1 antibody|Collagen alpha 1(III) chain antibody|Collagen alpha-1(III) chain antibody|Collagen III alpha 1 chain precursor antibody|Collagen III alpha 1 polypeptide antibody|Collagen type III alpha 1 (Ehlers Danlos syndrome type IV autosomal dominant) antibody|Collagen type III alpha 1 antibody|Collagen type III alpha 1 chain antibody|Collagen type III alpha antibody|Collagen, fetal antibody|EDS4A antibody|Ehlers Danlos syndrome type IV, autosomal dominant antibody|Fetal collagen antibody|Type III collagen antibody|Anti-Collagen III antibody (ab7778)
SCBT cat No: sc-271249|sc-8781|sc-514601|sc-28888|sc-8780|sc-52317|sc-70866|sc-59814|

 

Name

Cleaved-COL3A1 (G1221) Polyclonal Antibody

Catalogue No.

STJ90049

Reactivity

Human

Specificity

Cleaved-COL3A1 (G1221) Polyclonal Antibody detects endogenous levels of fragment of activated COL3A1 protein resulting from cleavage adjacent to G1221.

Immunogen

Synthesized peptide derived from Cleaved-COL3A1 (G1221) at AA range 1140-1220

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

95 kDa

Formulation

Cleaved-COL3A1 (G1221) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Cleaved-COL3A1 (G1221) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Collagen alpha-1antibody, III antibody, chain antibody

Database links

Human UniProt/Swiss-Prot:P02461;Mouse UniPort/Swiss-Prot: P08121;Rat UniProt/Swiss-Port: P13941;Human Entrez Gene: 1281;Mouse Entrez Gene: 12825;Rat Entrez Gene: Rn.3247

Protein names

Collagen alpha-1, III , chain

Protein function

Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of GPR56 in the developing brain and binding to GPR56 inhibits neuronal migration and activates the RhoA pathway by coupling GPR56 to GNA13 and possibly GNA12.

Involvement in disease

Ehlers-Danlos syndrome 3 (EDS3) [MIM:130020]: A connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. It is a form of Ehlers-Danlos syndrome characterized by marked joint hyperextensibility without skeletal deformity. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Ehlers-Danlos syndrome 4 (EDS4) [MIM:130050]: The most severe form of Ehlers-Danlos syndrome, a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. Characterized by the joint and dermal manifestations as in other forms of the syndrome, characteristic facial features (acrogeria) in most patients, and by proneness to spontaneous rupture of bowel and large arteries. The vascular complications may affect all anatomical areas. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Aortic aneurysm, familial abdominal (AAA) [MIM:100070]: A common multifactorial disorder characterized by permanent dilation of the abdominal aorta, usually due to degenerative changes in the aortic wall. Histologically, AAA is characterized by signs of chronic inflammation, destructive remodeling of the extracellular matrix, and depletion of vascular smooth muscle cells. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Protein sequence and domain

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function. / Belongs to the fibrillar collagen family. / Contains 1 fibrillar collagen NC1 domain. / Contains 1 VWFC domain.

Protein post-translational modifications

Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. / O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.

Protein cellular localization

Secreted > extracellular space > extracellular matrix

Research area

All research areas>Cell Adhesion Proteins>Collagen
(View all antibody categories related to Cell Adhesion Proteins)

Note

AntibodyPlus can customize Cleaved-COL3A1 (G1221) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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