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Rabbit Polyclonal Cleaved-Factor B Bb (K260) antibody (STJ90079)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for Cleaved-Factor B Bb (K260) Polyclonal Antibody.
Check alternative names for the antibodyExpand
CFB antibody, BF antibody, BFD antibody,|C3/C5 convertase antibody|Complement factor B antibody|Glycine-rich beta glycoprotein antibody|PBF2 antibody|Properdin factor B antibody|Anti-Complement factor B antibody [M13/12] (ab106139)
SCBT cat No: sc-69772|sc-57506|sc-47681|sc-271636|sc-67141|sc-47682|sc-47680|sc-34888|sc-47679|
Cleaved-Factor B Bb (K260) Polyclonal Antibody
|Catalogue No.|| |
Cleaved-Factor B Bb (K260) Polyclonal Antibody detects endogenous levels of fragment of activated Factor B Bb protein resulting from cleavage adjacent to K260.
Synthesized peptide derived from Cleaved-Factor B Bb (K260) at AA range 210-290
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:20000;
|Molecular weight|| |
Cleaved-Factor B Bb (K260) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cleaved-Factor B Bb (K260) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Complement factor B antibody, C3/C5 convertase antibody, Glycine-rich beta glycoprotein antibody, GBG antibody, PBF2 antibody, Properdin factor B antibody
|Protein names|| |
Complement factor B , C3/C5 convertase , Glycine-rich beta glycoprotein , GBG , PBF2 , Properdin factor B
|Protein function|| |
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. / Cleavage of Arg-, -Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-, -Xaa bond in complement component C5 alpha-chain to yield C5a and C5b.
|Involvement in disease|| |
Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]: An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.; Complement factor B deficiency (CFBD) [MIM:615561]: An immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The unliganded VWA domain has an inactive ‘locked’ conformation whereby the scissile Arg-259, Lys-260 bond is protected from proteolytic activation. / Belongs to the peptidase S1 family. / Contains 1 peptidase S1 domain. / Contains 3 Sushi (CCP/SCR) domains. / Contains 1 VWFA domain.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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