Rabbit Polyclonal Cleaved-Factor VII LC (R212) antibody (STJ90080)

$99.00$319.00

Reactivity: Human
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Cleaved-Factor VII LC (R212) antibody (STJ90080)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Cleaved-Factor VII LC (R212) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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F7 antibody,|coagulation factor VII (serum prothrombin conversion accelerator) antibody|Coagulation factor VII antibody|Eptacog alfa antibody|F7 antibody|FA7_HUMAN antibody|Factor VII antibody|Factor VII heavy chain antibody|Factor VII light chain antibody|FVII coagulation protein antibody|OTTHUMP00000018733 antibody|OTTHUMP00000018734 antibody|Proconvertin antibody|Serum prothrombin conversion accelerator antibody|SPCA antibody|Anti-Factor VII antibody (ab97614)
SCBT cat No: sc-366001|

 

Name

Cleaved-Factor VII LC (R212) Polyclonal Antibody

Catalogue No.

STJ90080

Reactivity

Human

Specificity

Cleaved-Factor VII LC (R212) Polyclonal Antibody detects endogenous levels of fragment of activated Factor VII LC protein resulting from cleavage adjacent to R212.

Immunogen

Synthesized peptide derived from Cleaved-Factor VII LC (R212) at AA range 140-220

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

17 kDa

Formulation

Cleaved-Factor VII LC (R212) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Cleaved-Factor VII LC (R212) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Coagulation factor VII antibody, Proconvertin antibody, Serum prothrombin conversion accelerator antibody, SPCA antibody, Eptacog alfa antibody

Database links

Human UniProt/Swiss-Prot:P08709;Mouse UniPort/Swiss-Prot: P70375;Rat UniProt/Swiss-Port: Q8K3U6;Human Entrez Gene: 2155;Mouse Entrez Gene: 14068;Rat Entrez Gene: Rn.86416

Protein names

Coagulation factor VII , Proconvertin , Serum prothrombin conversion accelerator , SPCA , Eptacog alfa

Protein function

Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. / Selective cleavage of Arg-, -Ile bond in factor X to form factor Xa.

Protein tissue specificity

Plasma.

Involvement in disease

Factor VII deficiency (FA7D) [MIM:227500]: A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the peptidase S1 family. / Contains 2 EGF-like domains. / Contains 1 Gla (gamma-carboxy-glutamate) domain. / Contains 1 peptidase S1 domain.

Protein post-translational modifications

The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. / The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. / O- and N-glycosylated. N-glycosylation at Asn-205 occurs cotranslationally and is mediated by STT3A-containing complexes, while glycosylation at Asn-382 is post-translational and is mediated STT3B-containing complexes before folding. O-fucosylated by POFUT1 on a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. / Can be either O-glucosylated or O-xylosylated at Ser-112 by POGLUT1 in vitro.

Protein cellular localization

Secreted

Research area

All research areas>Signaling Intermediates>Coagulation Factor
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize Cleaved-Factor VII LC (R212) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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