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Rabbit Polyclonal Cleaved-Factor VII LC (R212) antibody (STJ90080)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for Cleaved-Factor VII LC (R212) Polyclonal Antibody.
Check alternative names for the antibodyExpand
F7 antibody,|coagulation factor VII (serum prothrombin conversion accelerator) antibody|Coagulation factor VII antibody|Eptacog alfa antibody|F7 antibody|FA7_HUMAN antibody|Factor VII antibody|Factor VII heavy chain antibody|Factor VII light chain antibody|FVII coagulation protein antibody|OTTHUMP00000018733 antibody|OTTHUMP00000018734 antibody|Proconvertin antibody|Serum prothrombin conversion accelerator antibody|SPCA antibody|Anti-Factor VII antibody (ab97614)
SCBT cat No: sc-366001|
Cleaved-Factor VII LC (R212) Polyclonal Antibody
|Catalogue No.|| |
Cleaved-Factor VII LC (R212) Polyclonal Antibody detects endogenous levels of fragment of activated Factor VII LC protein resulting from cleavage adjacent to R212.
Synthesized peptide derived from Cleaved-Factor VII LC (R212) at AA range 140-220
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
|Molecular weight|| |
Cleaved-Factor VII LC (R212) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cleaved-Factor VII LC (R212) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Coagulation factor VII antibody, Proconvertin antibody, Serum prothrombin conversion accelerator antibody, SPCA antibody, Eptacog alfa antibody
|Protein names|| |
Coagulation factor VII , Proconvertin , Serum prothrombin conversion accelerator , SPCA , Eptacog alfa
|Protein function|| |
Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. / Selective cleavage of Arg-, -Ile bond in factor X to form factor Xa.
|Protein tissue specificity|| |
|Involvement in disease|| |
Factor VII deficiency (FA7D) [MIM:227500]: A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the peptidase S1 family. / Contains 2 EGF-like domains. / Contains 1 Gla (gamma-carboxy-glutamate) domain. / Contains 1 peptidase S1 domain.
|Protein post-translational modifications|| |
The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. / The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. / O- and N-glycosylated. N-glycosylation at Asn-205 occurs cotranslationally and is mediated by STT3A-containing complexes, while glycosylation at Asn-382 is post-translational and is mediated STT3B-containing complexes before folding. O-fucosylated by POFUT1 on a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. / Can be either O-glucosylated or O-xylosylated at Ser-112 by POGLUT1 in vitro.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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