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Rabbit Polyclonal Cleaved-Factor Xa activated HC (I235) antibody (STJ90082)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for Cleaved-Factor Xa activated HC (I235) Polyclonal Antibody.
Check alternative names for the antibodyExpand
F10 antibody,|Activated factor Xa heavy chain antibody|Coagulation factor X antibody|F10 antibody|FA10_HUMAN antibody|factor Xa antibody|FX antibody|FXA antibody|Prothrombinase antibody|Stuart factor antibody|Stuart Prower factor antibody|Stuart-Prower factor antibody|Anti-Factor X antibody (ab79929)
SCBT cat No: sc-101370|sc-69654|sc-65954|sc-20673|
Cleaved-Factor Xa activated HC (I235) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Cleaved-Factor Xa activated HC (I235) Polyclonal Antibody detects endogenous levels of fragment of activated Factor Xa activated HC protein resulting from cleavage adjacent to I235.
Synthesized peptide derived from Cleaved-Factor Xa activated HC (I235) at AA range 190-270
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:20000;
|Molecular weight|| |
Cleaved-Factor Xa activated HC (I235) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cleaved-Factor Xa activated HC (I235) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Coagulation factor X antibody, Stuart factor antibody, Stuart-Prower factor antibody
|Protein names|| |
Coagulation factor X , Stuart factor , Stuart-Prower factor
|Protein function|| |
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. / Selective cleavage of Arg-, -Thr and then Arg-, -Ile bonds in prothrombin to form thrombin. / Inhibited by SERPINA5 and SERPINA10.
|Protein tissue specificity|| |
Plasma; synthesized in the liver.
|Involvement in disease|| |
Factor X deficiency (FA10D) [MIM:227600]: A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the peptidase S1 family. / Contains 2 EGF-like domains. / Contains 1 Gla (gamma-carboxy-glutamate) domain. / Contains 1 peptidase S1 domain.
|Protein post-translational modifications|| |
The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. / N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. / The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway). / The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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