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Rabbit Polyclonal Cleaved-Factor XII HC (R372) antibody (STJ90084)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for Cleaved-Factor XII HC (R372) Polyclonal Antibody.
Check alternative names for the antibodyExpand
F12 antibody,|Coagulation factor XII antibody|Coagulation factor XIIa heavy chain antibody|F12 antibody|HAE3 antibody|HAEX antibody|HAF antibody|Hageman factor antibody|Anti-Factor XII heavy chain antibody [B7C9] (ab1007)
SCBT cat No: sc-65956|sc-135149|sc-66751|sc-66752|sc-59517|sc-59518|
Cleaved-Factor XII HC (R372) Polyclonal Antibody
|Catalogue No.|| |
Cleaved-Factor XII HC (R372) Polyclonal Antibody detects endogenous levels of fragment of activated Factor XII HC protein resulting from cleavage adjacent to R372.
Synthesized peptide derived from Cleaved-Factor XII HC (R372) at AA range 300-380
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:20000;
|Molecular weight|| |
Cleaved-Factor XII HC (R372) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cleaved-Factor XII HC (R372) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Coagulation factor XII antibody, Hageman factor antibody, HAF antibody
|Protein names|| |
Coagulation factor XII , Hageman factor , HAF
|Protein function|| |
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. / Selective cleavage of Arg-, -Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.
|Involvement in disease|| |
Factor XII deficiency (FA12D) [MIM:234000]: An asymptomatic anomaly of in vitro blood coagulation. Its diagnosis is based on finding a low plasma activity of the factor in coagulating assays. It is usually only accidentally discovered through pre-operative blood tests. Factor XII deficiency is divided into two categories, a cross-reacting material (CRM)-negative group (negative F12 antigen detection) and a CRM-positive group (positive F12 antigen detection). . Note: The disease is caused by mutations affecting the gene represented in this entry.; Hereditary angioedema 3 (HAE3) [MIM:610618]: An hereditary angioedema occurring only in women. Hereditary angioedema is an autosomal dominant disorder characterized by episodic local swelling involving subcutaneous or submucous tissue of the upper respiratory and gastrointestinal tracts, face, extremities, and genitalia. Hereditary angioedema type 3 differs from types 1 and 2 in that both concentration and function of C1 esterase inhibitor are normal. Hereditary angioedema type 3 is precipitated or worsened by high estrogen levels (e.g., during pregnancy or treatment with oral contraceptives). . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the peptidase S1 family. / Contains 2 EGF-like domains. / Contains 1 fibronectin type-I domain. / Contains 1 fibronectin type-II domain. / Contains 1 kringle domain. / Contains 1 peptidase S1 domain.
|Protein post-translational modifications|| |
Factor XII is activated by kallikrein in alpha-factor XIIa, which is further converted by trypsin into beta-factor XIIa. Alpha-factor XIIa is composed of an NH2-terminal heavy chain, called coagulation factor XIIa heavy chain, and a COOH-terminal light chain, called coagulation factor XIIa light chain, connected by a disulfide bond. Beta-factor XIIa is composed of 2 chains linked by a disulfide bond, an N-terminal nonapeptide, called beta-factor XIIa part 1, and coagulation factor XIIa light chain, also known in this context as beta-factor XIIa part 2. / O- and N-glycosylated. The O-linked polysaccharides were not identified, but are probably the mucin type linked to GalNAc.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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